Name: rs11045818
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs11045818

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr12:21176827 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: G>A
Variation Type: SNV Single Nucleotide Variation
Frequency: A=0.107771 (28526/264690, TOPMED)
A=0.111431 (27884/250236, GnomAD_exome)
A=0.149084 (32370/217126, ALFA) (+ 23 more)
A=0.111117 (15562/140050, GnomAD)
A=0.112778 (13641/120954, ExAC)
A=0.05921 (4660/78700, PAGE_STUDY)
A=0.12147 (1574/12958, GO-ESP)
A=0.0531 (340/6404, 1000G_30x)
A=0.0517 (259/5008, 1000G)
A=0.0949 (425/4480, Estonian)
A=0.1578 (608/3854, ALSPAC)
A=0.1688 (626/3708, TWINSUK)
A=0.0529 (171/3234, PRJNA289433)
A=0.0003 (1/2922, KOREAN)
A=0.1324 (197/1488, PharmGKB)
A=0.0666 (91/1366, HapMap)
A=0.184 (184/998, GoNL)
A=0.089 (56/626, Chileans)
A=0.143 (86/600, NorthernSweden)
A=0.103 (55/534, MGP)
A=0.066 (20/304, FINRISK)
A=0.051 (11/216, Qatari)
G=0.48 (21/44, SGDP_PRJ)
A=0.10 (4/40, GENOME_DK)
A=0.16 (6/38, Ancient Sardinia)
G=0.4 (3/8, Siberian)

Clinical Significance: Reported in ClinVar
Gene : Consequence: SLCO1B1 : Synonymous Variant
Publications: 4 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20231103111315

Population	Group	Sample Size	Ref Allele	Alt Allele	Ref HMOZ	Alt HMOZ	HTRZ	HWEP
Total	Global	238300	G=0.853584	A=0.146416	0.730575	0.023407	0.246018	16
European	Sub	194012	G=0.837773	A=0.162227	0.701977	0.026431	0.271591	0
African	Sub	16378	G=0.96251	A=0.03749	0.927219	0.002198	0.070582	3
African Others	Sub	600	G=0.983	A=0.017	0.966667	0.0	0.033333	0
African American	Sub	15778	G=0.96172	A=0.03828	0.925719	0.002282	0.071999	3
Asian	Sub	3476	G=0.9997	A=0.0003	0.999425	0.0	0.000575	0
East Asian	Sub	2778	G=0.9996	A=0.0004	0.99928	0.0	0.00072	0
Other Asian	Sub	698	G=1.000	A=0.000	1.0	0.0	0.0	N/A
Latin American 1	Sub	1356	G=0.8916	A=0.1084	0.79646	0.013274	0.190265	0
Latin American 2	Sub	7238	G=0.9282	A=0.0718	0.861288	0.004974	0.133739	0
South Asian	Sub	334	G=0.937	A=0.063	0.886228	0.011976	0.101796	2
Other	Sub	15506	G=0.86367	A=0.13633	0.75029	0.022959	0.226751	6

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	G=0.892229	A=0.107771
gnomAD - Exomes	Global	Study-wide	250236	G=0.888569	A=0.111431
gnomAD - Exomes	European	Sub	134454	G=0.845129	A=0.154871
gnomAD - Exomes	Asian	Sub	48958	G=0.97281	A=0.02719
gnomAD - Exomes	American	Sub	34520	G=0.93172	A=0.06828
gnomAD - Exomes	African	Sub	16186	G=0.96454	A=0.03546
gnomAD - Exomes	Ashkenazi Jewish	Sub	10038	G=0.79966	A=0.20034
gnomAD - Exomes	Other	Sub	6080	G=0.8704	A=0.1296
Allele Frequency Aggregator	Total	Global	217126	G=0.850916	A=0.149084
Allele Frequency Aggregator	European	Sub	181002	G=0.837355	A=0.162645
Allele Frequency Aggregator	Other	Sub	13290	G=0.86305	A=0.13695
Allele Frequency Aggregator	African	Sub	10430	G=0.95954	A=0.04046
Allele Frequency Aggregator	Latin American 2	Sub	7238	G=0.9282	A=0.0718
Allele Frequency Aggregator	Asian	Sub	3476	G=0.9997	A=0.0003
Allele Frequency Aggregator	Latin American 1	Sub	1356	G=0.8916	A=0.1084
Allele Frequency Aggregator	South Asian	Sub	334	G=0.937	A=0.063
gnomAD - Genomes	Global	Study-wide	140050	G=0.888883	A=0.111117
gnomAD - Genomes	European	Sub	75826	G=0.84557	A=0.15443
gnomAD - Genomes	African	Sub	42002	G=0.96184	A=0.03816
gnomAD - Genomes	American	Sub	13624	G=0.90238	A=0.09762
gnomAD - Genomes	Ashkenazi Jewish	Sub	3322	G=0.7881	A=0.2119
gnomAD - Genomes	East Asian	Sub	3128	G=0.9987	A=0.0013
gnomAD - Genomes	Other	Sub	2148	G=0.9018	A=0.0982
ExAC	Global	Study-wide	120954	G=0.887222	A=0.112778
ExAC	Europe	Sub	73100	G=0.83918	A=0.16082
ExAC	Asian	Sub	25142	G=0.97100	A=0.02900
ExAC	American	Sub	11516	G=0.94043	A=0.05957
ExAC	African	Sub	10296	G=0.96329	A=0.03671
ExAC	Other	Sub	900	G=0.898	A=0.102
The PAGE Study	Global	Study-wide	78700	G=0.94079	A=0.05921
The PAGE Study	AfricanAmerican	Sub	32516	G=0.95793	A=0.04207
The PAGE Study	Mexican	Sub	10810	G=0.92498	A=0.07502
The PAGE Study	Asian	Sub	8318	G=0.9986	A=0.0014
The PAGE Study	PuertoRican	Sub	7918	G=0.8974	A=0.1026
The PAGE Study	NativeHawaiian	Sub	4532	G=0.9521	A=0.0479
The PAGE Study	Cuban	Sub	4230	G=0.8674	A=0.1326
The PAGE Study	Dominican	Sub	3828	G=0.9013	A=0.0987
The PAGE Study	CentralAmerican	Sub	2450	G=0.9327	A=0.0673
The PAGE Study	SouthAmerican	Sub	1982	G=0.9142	A=0.0858
The PAGE Study	NativeAmerican	Sub	1260	G=0.8976	A=0.1024
The PAGE Study	SouthAsian	Sub	856	G=0.957	A=0.043
GO Exome Sequencing Project	Global	Study-wide	12958	G=0.87853	A=0.12147
GO Exome Sequencing Project	European American	Sub	8558	G=0.8378	A=0.1622
GO Exome Sequencing Project	African American	Sub	4400	G=0.9577	A=0.0423
1000Genomes_30x	Global	Study-wide	6404	G=0.9469	A=0.0531
1000Genomes_30x	African	Sub	1786	G=0.9866	A=0.0134
1000Genomes_30x	Europe	Sub	1266	G=0.8499	A=0.1501
1000Genomes_30x	South Asian	Sub	1202	G=0.9700	A=0.0300
1000Genomes_30x	East Asian	Sub	1170	G=0.9974	A=0.0026
1000Genomes_30x	American	Sub	980	G=0.911	A=0.089
1000Genomes	Global	Study-wide	5008	G=0.9483	A=0.0517
1000Genomes	African	Sub	1322	G=0.9864	A=0.0136
1000Genomes	East Asian	Sub	1008	G=0.9970	A=0.0030
1000Genomes	Europe	Sub	1006	G=0.8559	A=0.1441
1000Genomes	South Asian	Sub	978	G=0.968	A=0.032
1000Genomes	American	Sub	694	G=0.911	A=0.089
Genetic variation in the Estonian population	Estonian	Study-wide	4480	G=0.9051	A=0.0949
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.8422	A=0.1578
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.8312	A=0.1688
MxGDAR/Encodat-PGx	Global	Study-wide	3234	G=0.9471	A=0.0529
MxGDAR/Encodat-PGx	MxGDAR	Sub	3234	G=0.9471	A=0.0529
KOREAN population from KRGDB	KOREAN	Study-wide	2922	G=0.9997	A=0.0003
PharmGKB Aggregated	Global	Study-wide	1488	G=0.8676	A=0.1324
PharmGKB Aggregated	PA165066480	Sub	1400	G=0.8686	A=0.1314
PharmGKB Aggregated	PA142898898	Sub	88	G=0.85	A=0.15
HapMap	Global	Study-wide	1366	G=0.9334	A=0.0666
HapMap	American	Sub	596	G=0.896	A=0.104
HapMap	African	Sub	508	G=0.988	A=0.012
HapMap	Europe	Sub	174	G=0.868	A=0.132
HapMap	Asian	Sub	88	G=1.00	A=0.00
Genome of the Netherlands Release 5	Genome of the Netherlands	Study-wide	998	G=0.816	A=0.184
Chileans	Chilean	Study-wide	626	G=0.911	A=0.089
Northern Sweden	ACPOP	Study-wide	600	G=0.857	A=0.143
Medical Genome Project healthy controls from Spanish population	Spanish controls	Study-wide	534	G=0.897	A=0.103
FINRISK	Finnish from FINRISK project	Study-wide	304	G=0.934	A=0.066
Qatari	Global	Study-wide	216	G=0.949	A=0.051
SGDP_PRJ	Global	Study-wide	44	G=0.48	A=0.52
The Danish reference pan genome	Danish	Study-wide	40	G=0.90	A=0.10
Ancient Sardinia genome-wide 1240k capture data generation and analysis	Global	Study-wide	38	G=0.84	A=0.16
Siberian	Global	Study-wide	8	G=0.4	A=0.6

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 12	NC_000012.12:g.21176827G>A
GRCh37.p13 chr 12	NC_000012.11:g.21329761G>A
SLCO1B1 RefSeqGene (LRG_1022)	NG_011745.1:g.50634G>A

Gene: SLCO1B1, solute carrier organic anion transporter family member 1B1 (plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
SLCO1B1 transcript	NM_006446.5:c.411G>A	S [TCG] > S [TCA]	Coding Sequence Variant
solute carrier organic anion transporter family member 1B1	NP_006437.3:p.Ser137=	S (Ser) > S (Ser)	Synonymous Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: A (allele ID: 330068 )

ClinVar Accession	Disease Names	Clinical Significance
RCV000310218.9	Rotor syndrome	Benign
RCV001535078.2	not provided	Benign

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	G=	A
GRCh38.p14 chr 12	NC_000012.12:g.21176827=	NC_000012.12:g.21176827G>A
GRCh37.p13 chr 12	NC_000012.11:g.21329761=	NC_000012.11:g.21329761G>A
SLCO1B1 RefSeqGene (LRG_1022)	NG_011745.1:g.50634=	NG_011745.1:g.50634G>A
SLCO1B1 transcript	NM_006446.5:c.411=	NM_006446.5:c.411G>A
SLCO1B1 transcript	NM_006446.4:c.411=	NM_006446.4:c.411G>A
solute carrier organic anion transporter family member 1B1	NP_006437.3:p.Ser137=	NP_006437.3:p.Ser137=

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

113 SubSNP, 26 Frequency, 2 ClinVar submissions

No	Submitter	Submission ID	Date (Build)
1	SC_SNP	ss15510703	Feb 27, 2004 (120)
2	SC_SNP	ss18962592	Feb 27, 2004 (120)
3	PERLEGEN	ss24436880	Sep 20, 2004 (123)
4	AFFY	ss66120109	Nov 30, 2006 (127)
5	PHARMGKB_PAAR-SJCRH	ss69368414	May 17, 2007 (127)
6	ILLUMINA	ss75072445	Dec 07, 2007 (129)
7	AFFY	ss76112317	Dec 07, 2007 (129)
8	KRIBB_YJKIM	ss82836254	Dec 14, 2007 (130)
9	HUMANGENOME_JCVI	ss97292835	Feb 05, 2009 (130)
10	CNG	ss98335762	Feb 05, 2009 (130)
11	PMT	ss120239922	Dec 01, 2009 (131)
12	ENSEMBL	ss139904495	Dec 01, 2009 (131)
13	ILLUMINA	ss159951228	Dec 01, 2009 (131)
14	PHARMGKB_PAAR-UCHI	ss161109945	Dec 01, 2009 (131)
15	COMPLETE_GENOMICS	ss170546294	Jul 04, 2010 (132)
16	ILLUMINA	ss170955789	Jul 04, 2010 (132)
17	AFFY	ss172543619	Jul 04, 2010 (132)
18	1000GENOMES	ss225644844	Jul 14, 2010 (132)
19	1000GENOMES	ss235854348	Jul 15, 2010 (132)
20	GMI	ss286521387	Apr 25, 2013 (138)
21	PJP	ss291397128	May 09, 2011 (134)
22	NHLBI-ESP	ss342351440	May 09, 2011 (134)
23	ILLUMINA	ss479446220	May 04, 2012 (137)
24	ILLUMINA	ss479870941	Sep 08, 2015 (146)
25	1000GENOMES	ss491038265	May 04, 2012 (137)
26	CLINSEQ_SNP	ss491661692	May 04, 2012 (137)
27	ILLUMINA	ss533193078	Sep 08, 2015 (146)
28	ILLUMINA	ss831958386	Sep 08, 2015 (146)
29	EVA-GONL	ss989317036	Aug 21, 2014 (142)
30	JMKIDD_LAB	ss1067532205	Aug 21, 2014 (142)
31	JMKIDD_LAB	ss1078305414	Aug 21, 2014 (142)
32	1000GENOMES	ss1344205389	Aug 21, 2014 (142)
33	EVA_GENOME_DK	ss1576155892	Apr 01, 2015 (144)
34	EVA_FINRISK	ss1584080710	Apr 01, 2015 (144)
35	EVA_DECODE	ss1598989754	Apr 01, 2015 (144)
36	EVA_UK10K_ALSPAC	ss1628166958	Apr 01, 2015 (144)
37	EVA_UK10K_TWINSUK	ss1671160991	Apr 01, 2015 (144)
38	EVA_EXAC	ss1690819628	Apr 01, 2015 (144)
39	EVA_MGP	ss1711323285	Apr 01, 2015 (144)
40	EVA_SVP	ss1713312648	Apr 01, 2015 (144)
41	ILLUMINA	ss1752059971	Sep 08, 2015 (146)
42	WEILL_CORNELL_DGM	ss1932681507	Feb 12, 2016 (147)
43	ILLUMINA	ss1946333525	Feb 12, 2016 (147)
44	ILLUMINA	ss1959419463	Feb 12, 2016 (147)
45	JJLAB	ss2027088108	Sep 14, 2016 (149)
46	ILLUMINA	ss2095032089	Dec 20, 2016 (150)
47	USC_VALOUEV	ss2155413860	Dec 20, 2016 (150)
48	HUMAN_LONGEVITY	ss2188375161	Dec 20, 2016 (150)
49	ILLUMINA	ss2632934595	Nov 08, 2017 (151)
50	ILLUMINA	ss2632934596	Nov 08, 2017 (151)
51	ILLUMINA	ss2710756083	Nov 08, 2017 (151)
52	GNOMAD	ss2739675621	Nov 08, 2017 (151)
53	GNOMAD	ss2748826217	Nov 08, 2017 (151)
54	GNOMAD	ss2908174490	Nov 08, 2017 (151)
55	AFFY	ss2985612465	Nov 08, 2017 (151)
56	SWEGEN	ss3009330228	Nov 08, 2017 (151)
57	ILLUMINA	ss3021413006	Nov 08, 2017 (151)
58	BIOINF_KMB_FNS_UNIBA	ss3027350321	Nov 08, 2017 (151)
59	CSHL	ss3349960640	Nov 08, 2017 (151)
60	ILLUMINA	ss3625617350	Oct 12, 2018 (152)
61	ILLUMINA	ss3626833355	Oct 12, 2018 (152)
62	ILLUMINA	ss3633013281	Oct 12, 2018 (152)
63	ILLUMINA	ss3633713883	Oct 12, 2018 (152)
64	ILLUMINA	ss3634494915	Oct 12, 2018 (152)
65	ILLUMINA	ss3635404856	Oct 12, 2018 (152)
66	ILLUMINA	ss3636179225	Oct 12, 2018 (152)
67	ILLUMINA	ss3637155814	Oct 12, 2018 (152)
68	ILLUMINA	ss3637951501	Oct 12, 2018 (152)
69	ILLUMINA	ss3640202248	Oct 12, 2018 (152)
70	ILLUMINA	ss3642946070	Oct 12, 2018 (152)
71	ILLUMINA	ss3644586485	Oct 12, 2018 (152)
72	OMUKHERJEE_ADBS	ss3646439195	Oct 12, 2018 (152)
73	URBANLAB	ss3649786496	Oct 12, 2018 (152)
74	ILLUMINA	ss3651787125	Oct 12, 2018 (152)
75	ILLUMINA	ss3651787126	Oct 12, 2018 (152)
76	EGCUT_WGS	ss3676645998	Jul 13, 2019 (153)
77	EVA_DECODE	ss3693259733	Jul 13, 2019 (153)
78	ACPOP	ss3738837088	Jul 13, 2019 (153)
79	ILLUMINA	ss3744096292	Jul 13, 2019 (153)
80	ILLUMINA	ss3744795628	Jul 13, 2019 (153)
81	EVA	ss3750230587	Jul 13, 2019 (153)
82	PAGE_CC	ss3771679143	Jul 13, 2019 (153)
83	ILLUMINA	ss3772295152	Jul 13, 2019 (153)
84	KHV_HUMAN_GENOMES	ss3815548195	Jul 13, 2019 (153)
85	EVA	ss3824711157	Apr 26, 2020 (154)
86	EVA	ss3825817687	Apr 26, 2020 (154)
87	EVA	ss3833014590	Apr 26, 2020 (154)
88	SGDP_PRJ	ss3877844634	Apr 26, 2020 (154)
89	KRGDB	ss3926377256	Apr 26, 2020 (154)
90	FSA-LAB	ss3984023419	Apr 26, 2021 (155)
91	EVA	ss3984449714	Apr 26, 2021 (155)
92	EVA	ss3985579644	Apr 26, 2021 (155)
93	EVA	ss3986562203	Apr 26, 2021 (155)
94	EVA	ss4017578094	Apr 26, 2021 (155)
95	TOPMED	ss4911206323	Apr 26, 2021 (155)
96	EVA	ss5237219028	Apr 26, 2021 (155)
97	EVA	ss5237659606	Oct 13, 2022 (156)
98	1000G_HIGH_COVERAGE	ss5290064482	Oct 13, 2022 (156)
99	EVA	ss5314391658	Oct 13, 2022 (156)
100	TRAN_CS_UWATERLOO	ss5314434914	Oct 13, 2022 (156)
101	HUGCELL_USP	ss5484924544	Oct 13, 2022 (156)
102	EVA	ss5510619765	Oct 13, 2022 (156)
103	EVA	ss5512473920	Oct 13, 2022 (156)
104	1000G_HIGH_COVERAGE	ss5587120828	Oct 13, 2022 (156)
105	SANFORD_IMAGENETICS	ss5652739652	Oct 13, 2022 (156)
106	EVA	ss5799866319	Oct 13, 2022 (156)
107	EVA	ss5800064723	Oct 13, 2022 (156)
108	EVA	ss5837690625	Oct 13, 2022 (156)
109	EVA	ss5847662849	Oct 13, 2022 (156)
110	EVA	ss5848347704	Oct 13, 2022 (156)
111	EVA	ss5903573686	Oct 13, 2022 (156)
112	EVA	ss5944090220	Oct 13, 2022 (156)
113	EVA	ss5980726510	Oct 13, 2022 (156)
114	1000Genomes	NC_000012.11 - 21329761	Oct 12, 2018 (152)
115	1000Genomes_30x	NC_000012.12 - 21176827	Oct 13, 2022 (156)
116	The Avon Longitudinal Study of Parents and Children	NC_000012.11 - 21329761	Oct 12, 2018 (152)
117	Chileans	NC_000012.11 - 21329761	Apr 26, 2020 (154)
118	Genetic variation in the Estonian population	NC_000012.11 - 21329761	Oct 12, 2018 (152)
119	ExAC	NC_000012.11 - 21329761	Oct 12, 2018 (152)
120	FINRISK	NC_000012.11 - 21329761	Apr 26, 2020 (154)
121	The Danish reference pan genome	NC_000012.11 - 21329761	Apr 26, 2020 (154)
122	gnomAD - Genomes	NC_000012.12 - 21176827	Apr 26, 2021 (155)
123	gnomAD - Exomes	NC_000012.11 - 21329761	Jul 13, 2019 (153)
124	GO Exome Sequencing Project	NC_000012.11 - 21329761	Oct 12, 2018 (152)
125	Genome of the Netherlands Release 5	NC_000012.11 - 21329761	Apr 26, 2020 (154)
126	HapMap	NC_000012.12 - 21176827	Apr 26, 2020 (154)
127	KOREAN population from KRGDB	NC_000012.11 - 21329761	Apr 26, 2020 (154)
128	Medical Genome Project healthy controls from Spanish population	NC_000012.11 - 21329761	Apr 26, 2020 (154)
129	Northern Sweden	NC_000012.11 - 21329761	Jul 13, 2019 (153)
130	The PAGE Study	NC_000012.12 - 21176827	Jul 13, 2019 (153)
131	Ancient Sardinia genome-wide 1240k capture data generation and analysis	NC_000012.11 - 21329761	Apr 26, 2021 (155)
132	MxGDAR/Encodat-PGx	NC_000012.11 - 21329761	Apr 26, 2021 (155)
133	PharmGKB Aggregated	NC_000012.12 - 21176827	Apr 26, 2020 (154)
134	Qatari	NC_000012.11 - 21329761	Apr 26, 2020 (154)
135	SGDP_PRJ	NC_000012.11 - 21329761	Apr 26, 2020 (154)
136	Siberian	NC_000012.11 - 21329761	Apr 26, 2020 (154)
137	TopMed	NC_000012.12 - 21176827	Apr 26, 2021 (155)
138	UK 10K study - Twins	NC_000012.11 - 21329761	Oct 12, 2018 (152)
139	ALFA	NC_000012.12 - 21176827	Apr 26, 2021 (155)
140	ClinVar	RCV000310218.9	Oct 13, 2022 (156)
141	ClinVar	RCV001535078.2	Oct 13, 2022 (156)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs17330010	Oct 08, 2004 (123)
rs58004452	Feb 26, 2009 (130)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
ss66120109, ss76112317, ss170546294, ss172543619, ss286521387, ss291397128, ss491661692, ss1598989754, ss1713312648, ss3642946070	NC_000012.10:21221027:G:A	NC_000012.12:21176826:G:A	(self)
56923986, 31607566, 94339, 22384246, 1109569, 77171, 2875599, 8903554, 1168642, 14103381, 33554650, 439045, 12121953, 805571, 2715, 14723437, 29861614, 7930214, 31607566, ss225644844, ss235854348, ss342351440, ss479446220, ss479870941, ss491038265, ss533193078, ss831958386, ss989317036, ss1067532205, ss1078305414, ss1344205389, ss1576155892, ss1584080710, ss1628166958, ss1671160991, ss1690819628, ss1711323285, ss1752059971, ss1932681507, ss1946333525, ss1959419463, ss2027088108, ss2095032089, ss2155413860, ss2632934595, ss2632934596, ss2710756083, ss2739675621, ss2748826217, ss2908174490, ss2985612465, ss3009330228, ss3021413006, ss3349960640, ss3625617350, ss3626833355, ss3633013281, ss3633713883, ss3634494915, ss3635404856, ss3636179225, ss3637155814, ss3637951501, ss3640202248, ss3644586485, ss3646439195, ss3651787125, ss3651787126, ss3676645998, ss3738837088, ss3744096292, ss3744795628, ss3750230587, ss3772295152, ss3824711157, ss3825817687, ss3833014590, ss3877844634, ss3926377256, ss3984023419, ss3984449714, ss3985579644, ss3986562203, ss4017578094, ss5314391658, ss5510619765, ss5512473920, ss5652739652, ss5799866319, ss5800064723, ss5837690625, ss5847662849, ss5848347704, ss5944090220, ss5980726510	NC_000012.11:21329760:G:A	NC_000012.12:21176826:G:A	(self)
RCV000310218.9, RCV001535078.2, 74646763, 401379537, 771111, 900612, 2674, 126751980, 3083486903, ss2188375161, ss3027350321, ss3649786496, ss3693259733, ss3771679143, ss3815548195, ss4911206323, ss5237219028, ss5237659606, ss5290064482, ss5314434914, ss5484924544, ss5587120828, ss5903573686	NC_000012.12:21176826:G:A	NC_000012.12:21176826:G:A	(self)
ss15510703, ss18962592	NT_009714.16:14088734:G:A	NC_000012.12:21176826:G:A	(self)
ss24436880, ss69368414, ss75072445, ss82836254, ss97292835, ss98335762, ss120239922, ss139904495, ss159951228, ss161109945, ss170955789	NT_009714.17:14089884:G:A	NC_000012.12:21176826:G:A	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

4 citations for rs11045818

PMID	Title	Author	Year	Journal
19901119	Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.	Treviño LR et al.	2009	Journal of clinical oncology
23233662	Genome-wide study of methotrexate clearance replicates SLCO1B1.	Ramsey LB et al.	2013	Blood
23940529	Roles of genetic polymorphisms in the folate pathway in childhood acute lymphoblastic leukemia evaluated by Bayesian relevance and effect size analysis.	Lautner-Csorba O et al.	2013	PloS one
36055153	SLCO1B1 and SLC10A1 polymorphism and plasma rifampin concentrations in patients with co-morbidity tuberculosis-diabetes mellitus in Baja California, Mexico.	Perea-Jacobo R et al.	2022	Tuberculosis (Edinburgh, Scotland)

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:

Select flank length:

Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

Reference SNP (rs) Report

rs11045818