|
| Status |
Public on Mar 23, 2018 |
| Title |
RNA Misplicing in Fuchs Endothelial Corneal Dystrophy II |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA-Seq splicing data from the corneal endothelia of FECD patients and controls reveal hundreds of differential alternative splicing events. These include events previously characterized in the context of myotonic dystrophy type 1 and epithelial-to-mesenchymal transition, as well as splicing changes in genes related to proposed mechanisms of FECD pathogenesis.
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| |
|
| Overall design |
RNA-Seq was used to compare corneal endothelial specimens from subjects with Fuchs endothelial corneal dystrophy. Control samples from normal subjects were also provided.
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| |
|
| Contributor(s) |
Fautsch MP, Baratz KH, Wieben ED |
| Citation(s) |
29966009, 31469403, 28118661 |
| |
| Submission date |
Mar 22, 2018 |
| Last update date |
Nov 24, 2020 |
| Contact name |
Xiaojia Tang |
| E-mail(s) |
[email protected]
|
| Organization name |
Mayo Clinic
|
| Street address |
200 1st ST SW
|
| City |
Rochester |
| State/province |
MN |
| ZIP/Postal code |
55905 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (28)
|
|
| Relations |
| BioProject |
PRJNA445238 |
| SRA |
SRP136239 |
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