› 4hpo

X-ray diffraction
1.69Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-515644 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
CH58 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 231 amino acids
Theoretical weight: 25.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
CH58 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 23.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Envelope glycoprotein gp160 Chain: P
Molecule details ›
Chain: P
Length: 19 amino acids
Theoretical weight: 2.35 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: G9HS63 (Residues: 166-184; Coverage: 2%)
Gene name: env

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2
Unit cell:
a: 140.594Å b: 75.804Å c: 54.688Å
α: 90° β: 111.99° γ: 90°
R-values:
R R work R free
0.187 0.185 0.211
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

56 review citations

HIV-1 neutralizing antibodies: understanding nature's pathways.
Mascola et al. (2013)
55 more

14 mentions without citation

Insights into the Structural Basis of Antibody Affinity Maturation from Next-Generation Sequencing.
Mishra et al. (2018)
13 more