AmiGO 2: Term Details for "SREBP-SCAP complex retention in endoplasmic reticulum" (GO:0036316)

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Term Information

Accession: GO:0036316
Name: SREBP-SCAP complex retention in endoplasmic reticulum
Ontology: biological_process
Synonyms: None
Alternate IDs: None
Definition: Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER. Source: GOC:bf, PMID:16525117
Comment: Consider also annotating to the cellular component term: SREBP-SCAP-Insig complex ; GO:0032937.
History: See term history for GO:0036316 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to SREBP-SCAP complex retention in endoplasmic reticulum (excluding "regulates").; Link to all direct and indirect annotations to SREBP-SCAP complex retention in endoplasmic reticulum (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for SREBP-SCAP complex retention in endoplasmic reticulum (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
GO:0051179 localization
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
GO:0007154 cell communication
GO:0051641 cellular localization
GO:0009987 cellular process
CARO:0000003 connected anatomical structure
GO:0033036 macromolecule localization
UBERON:0000465 material anatomical entity
GO:0048519 negative regulation of biological process
GO:0050789 regulation of biological process
GO:0050794 regulation of cellular process
GO:0050896 response to stimulus
GO:0023052 signaling
UBERON:0000061 anatomical structure
CL:0000000 cell
GO:0110165 cellular anatomical structure
GO:0070727 cellular macromolecule localization
GO:0051716 cellular response to stimulus
GO:0005575 cellular_component
GO:0005622 intracellular anatomical structure
GO:0051235 maintenance of location
GO:0048523 negative regulation of cellular process
GO:0043226 organelle
GO:0008104 protein localization
GO:0010646 regulation of cell communication
GO:0048583 regulation of response to stimulus
GO:0023051 regulation of signaling
GO:0006950 response to stress
GO:0007165 signal transduction
GO:0033554 cellular response to stress
GO:0043229 intracellular organelle
GO:0035556 intracellular signal transduction
GO:0051651 maintenance of location in cell
GO:0045185 maintenance of protein location
GO:0043227 membrane-bounded organelle
GO:0010648 negative regulation of cell communication
GO:0048585 negative regulation of response to stimulus
GO:0023057 negative regulation of signaling
GO:0080134 regulation of response to stress
GO:0009966 regulation of signal transduction
GO:0042221 response to chemical
GO:0006991 response to sterol depletion
GO:0070887 cellular response to chemical stimulus
GO:0071501 cellular response to sterol depletion
GO:0005737 cytoplasm
GO:0012505 endomembrane system
GO:0006984 ER-nucleus signaling pathway
GO:0043231 intracellular membrane-bounded organelle
GO:0032507 maintenance of protein location in cell
GO:0009968 negative regulation of signal transduction
GO:0033365 protein localization to organelle
GO:0080135 regulation of cellular response to stress
GO:1902531 regulation of intracellular signal transduction
GO:0033993 response to lipid
GO:0014070 response to organic cyclic compound
GO:1901700 response to oxygen-containing compound
GO:0032933 SREBP signaling pathway
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:1901701 cellular response to oxygen-containing compound
GO:0005783 endoplasmic reticulum
GO:0072595 maintenance of protein localization in organelle
GO:1902532 negative regulation of intracellular signal transduction
GO:0070972 protein localization to endoplasmic reticulum
GO:2000638 regulation of SREBP signaling pathway
GO:0036314 response to sterol
GO:0036315 cellular response to sterol
GO:0035437 maintenance of protein localization in endoplasmic reticulum
GO:2000639 negative regulation of SREBP signaling pathway
GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum

Parents of SREBP-SCAP complex retention in endoplasmic reticulum (GO:0036316)

subject	relation	object
SREBP-SCAP complex retention in endoplasmic reticulum	is_a	maintenance of protein localization in endoplasmic reticulum (GO:0035437)
SREBP-SCAP complex retention in endoplasmic reticulum	BFO:0000050	cellular response to sterol (GO:0036315)
SREBP-SCAP complex retention in endoplasmic reticulum	is_a	negative regulation of SREBP signaling pathway (GO:2000639)
SREBP-SCAP complex retention in endoplasmic reticulum	RO:0002162	Eukaryota (NCBITaxon:2759)

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