› 2nct

Solution NMR

NMR assignment and structure of a peptide derived from the membrane proximal external region of HIV-1 gp41 in the presence of hexafluoroisopropanol

Released:
DOI: 10.2210/pdb2nct/pdb
PDB entry 2nct coloured by chain, ensemble of 20 models, front view.
PDB entry 2nct coloured by chain, ensemble of 20 models, side view.
PDB entry 2nct coloured by chain, ensemble of 20 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface.
Rujas E, Caaveiro JM, Partida-Hanon A, Gulzar N, Morante K, Apellániz B, García-Porras M, Bruix M, Tsumoto K, Scott JK, Jiménez MÁ, Nieva JL
OpenAccess logo Sci Rep 6 38177 (2016)
PMID: 27905530

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-563483 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Envelope glycoprotein Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 4.62 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: Q66X49 (Residues: 95-121; Coverage: 20%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 74%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

4 review citations

The expanding array of HIV broadly neutralizing antibodies.
McCoy LE. (2018)
3 more

1 mention without citation

Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface.
Rujas et al. (2016)