6v2p

X-ray diffraction
1.3Å resolution

HLA-B*57:03 presenting the peptide ASLNLPAVSW

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-516076 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: I3ZN84 (Residues: 25-300; Coverage: 82%)
Gene names: HLA-B, HLA-B*5703GB
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Catenin alpha-1 Chain: C
Molecule details ›
Chain: C
Length: 10 amino acids
Theoretical weight: 1.06 KDa
Source organism: synthetic construct
Expression system: synthetic construct
UniProt:
  • Canonical: P35221 (Residues: 850-859; Coverage: 1%)
Gene name: CTNNA1

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 50.981Å b: 82.277Å c: 110.866Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.136 0.134 0.163
Expression systems:
  • Escherichia coli BL21
  • synthetic construct