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Car9 Gene Detail
Summary
  • Symbol
    Car9
  • Name
    carbonic anhydrase 9
  • Synonyms
    CAIX, MN/CA9
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447188
    NCBI Gene: 230099
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43507026-43513729 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    301 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447188
 protein coding gene Chr4:43506966-43513729 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028210
 protein coding gene Chr4:41626694-41634338 (+)
A/J MGP_AJ_G0028166
 protein coding gene Chr4:40148880-40155610 (+)
AKR/J MGP_AKRJ_G0028118
 protein coding gene Chr4:41061211-41067965 (+)
BALB/cJ MGP_BALBcJ_G0028186
 protein coding gene Chr4:40236339-40243408 (+)
C3H/HeJ MGP_C3HHeJ_G0027908
 protein coding gene Chr4:41686550-41693208 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028627
 protein coding gene Chr4:43186109-43196332 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025939
 protein coding gene Chr4:37596691-37603518 (+)
CAST/EiJ MGP_CASTEiJ_G0027348
 protein coding gene Chr4:41190373-41198880 (+)
CBA/J MGP_CBAJ_G0027874
 protein coding gene Chr4:44494475-44503059 (+)
DBA/2J MGP_DBA2J_G0028023
 protein coding gene Chr4:40057367-40064194 (+)
FVB/NJ MGP_FVBNJ_G0027990
 protein coding gene Chr4:39279292-39285905 (+)
LP/J MGP_LPJ_G0028122
 protein coding gene Chr4:41675374-41686375 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028014
 protein coding gene Chr4:47760155-47767894 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028663
 protein coding gene Chr4:41256937-41264542 (+)
PWK/PhJ MGP_PWKPhJ_G0027074
 protein coding gene Chr4:40101736-40108500 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0027428
 protein coding gene Chr4:41158418-41166313 (+)



Homology
more
  • Human Ortholog
    CA9, carbonic anhydrase 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CA9, carbonic anhydrase 9
  • Synonyms
    CAIX, MN
  • Links
    NCBI Gene ID: 768
    neXtProt AC: NX_Q16790
    UniProt: Q16790

  • Chr Location
    9p13.3; chr9:35673928-35681159 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CA9 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation are viable and fertile but develop hyperplasia of the glandular gastric epithelium with numerous cysts. Mice homozygous for a different mutation show an increased mean percentage of mature B cells in bone marrow.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    48
  • cDNA Data
    22
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230099 NCBI Gene Model | MGI Sequence Detail 6704 C57BL/6J ±  kb
    transcript NM_139305 RefSeq | MGI Sequence Detail 1959 C57BL/6  
    polypeptide Q8VHB5 UniProt | EBI | MGI Sequence Detail 437 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 22
      Primer pair 5

      Microarray probesets 3
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 14
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:80329 Gut MO, et al., Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9. Gastroenterology. 2002 Dec;123(6):1889-903
    • Latest
      J:343328 Xie Z, et al., ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory