Niclosamide: an established antihelminthic drug as a potential therapy against S100A4-mediated metastatic colon tumors

J Natl Cancer Inst. 2011 Jul 6;103(13):991-2. doi: 10.1093/jnci/djr221. Epub 2011 Jun 17.
No abstract available

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • Anthelmintics / pharmacology
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism*
  • Cell Line, Tumor
  • Cell Movement / drug effects
  • Colonic Neoplasms / drug therapy*
  • Colonic Neoplasms / metabolism*
  • Colonic Neoplasms / pathology
  • Disease Progression
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • Liver Neoplasms / prevention & control*
  • Liver Neoplasms / secondary
  • Mice
  • Neoplasm Invasiveness
  • Niclosamide / administration & dosage
  • Niclosamide / chemistry
  • Niclosamide / pharmacology*
  • Prognosis
  • RNA, Messenger / metabolism
  • S100 Calcium-Binding Protein A4
  • S100 Proteins / genetics
  • S100 Proteins / metabolism*
  • Signal Transduction / drug effects
  • Transplantation, Heterologous
  • Wnt Proteins / drug effects
  • Wnt Proteins / metabolism
  • beta Catenin / drug effects
  • beta Catenin / metabolism

Substances

  • Anthelmintics
  • Antineoplastic Agents
  • Biomarkers, Tumor
  • CTNNB1 protein, human
  • RNA, Messenger
  • S100 Calcium-Binding Protein A4
  • S100 Proteins
  • Wnt Proteins
  • beta Catenin
  • S100A4 protein, human
  • Niclosamide