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1997-2010 Roel Nusse (rnusse-at-stanford.edu)
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December
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See History for timeline additions
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Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis. Insights into the mechanisms of Wnt action have emerged from several systems: genetics in Drosophila and Caenorhabditis elegans; biochemistry in cell culture and ectopic gene expression in Xenopus embryos. Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by abnormal Wnt signaling. As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP families on the cell surface. Through several cytoplasmic relay components, the signal is transduced to beta-catenin, which enters the nucleus and forms a complex with TCF to activate transcription of Wnt target genes (see diagrams of the Wnt pathway). Wnt signaling is discussed in many reviews, listed here. This website serves as a resource for members of the Wnt community, providing information on progress in the field, maps on signaling pathways, methods and various other items. See History for timeline of additions to the site.
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Genes, Proteins, Methods
| Wnt signaling
December 2009 |
Protein
interactions
December 2009 |
Wnt in
cancer
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