G6B

G6B
Identifikatori
Aliasi	MPIG6B
Vanjski ID-jevi	OMIM: 606520 MGI: 2146995 HomoloGene: 82249 GeneCards: MPIG6B
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	31,726,714 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	35,285,160 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• heparin binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • ćelijska membrana; • Endoplazmatski retikulum; • membrana; • Golđijev aparat;
Biološki proces	• platelet activation; • negative regulation of signal transduction; • integrin-mediated signaling pathway; • Koagulacija (krv); • erythrocyte differentiation; • megakaryocyte differentiation; • platelet formation; • megakaryocyte development;
	Izvori:Amigo / QuickGO
Ortolozi
	80739
	106722
ENSG00000206396; ENSG00000224393; ENSG00000204420; ENSG00000237459; ENSG00000230060;
	ENSG00000228090; ENSG00000231003
	ENSMUSG00000073414
	O95866
	D7PDD4
NM_025260; NM_138272; NM_138273; NM_138274; NM_138275;
	NM_138276; NM_138277
	NM_001033221; NM_001191012
NP_079536; NP_612116; NP_612117; NP_612118; NP_612119;
	NP_612121; NP_079536.2; NP_612116.1; NP_612117.1; NP_612118.1; NP_612119.1; NP_612121.1
	NP_001028393; NP_001177941
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

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Protein G6b jest protein koji je kod ljudi kodiran genom G6B ili C6orf25.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 241 aminokiselina, а molekulska težina 26.163 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAVFLQLLPL	LLSRAQGNPG	ASLDGRPGDR	VNLSCGGVSH	PIRWVWAPSF
PACKGLSKGR	RPILWASSSG	TPTVPPLQPF	VGRLRSLDSG	IRRLELLLSA
GDSGTFFCKG	RHEDESRTVL	HVLGDRTYCK	APGPTHGSVY	PQLLIPLLGA
GLVLGLGALG	LVWWLHRRLP	PQPIRPLPRF	APLVKTEPQR	PVKEEEPKIP
GDLDQEPSLL	YADLDHLALS	RPRRLSTADP	ADASTIYAVV	V

Funkcija

Ovaj gen je član natporodice imunoglobulina (Ig) i nalazi se u regiji klase III glavnog kompleksa histokompatibilnosti (MHC). Protein kodiran ovim genom je glikozilirani receptor ćelijske površine vezan za plazmamembranu, ali su topljive izoforme kodirane nekim varijantama transkripta u endoplazmatskom retikulumu i Golgijevom aparatu prije izlučivanja. Za ovaj gen pronađeno je više varijanti transkripta koje kodiraju različite izoforme.^[7]

Reference

^ ^a ^b ^c ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 GRCh38: Ensembl release 89: ENSG00000206396, ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073414 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ribas G, Neville M, Wixon JL, Cheng J, Campbell RD (Jul 1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". J Immunol. 163 (1): 278–87. PMID 10384126.
^ de Vet EC, Aguado B, Campbell RD (Nov 2001). "G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2". J Biol Chem. 276 (45): 42070–6. doi:10.1074/jbc.M103214200. PMID 11544253.
^ ^a ^b "Entrez Gene: C6orf25 chromosome 6 open reading frame 25".
^ "UniProt, O95866" (jezik: engleski). Zanemaren tekst "2021-10-02" (pomoć)

Dopunska literatura

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
de Vet EC, Newland SA, Lyons PA, et al. (2005). "The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin". FEBS Lett. 579 (11): 2355–8. doi:10.1016/j.febslet.2005.03.032. PMID 15848171. S2CID 24445026.
Newland SA, Macaulay IC, Floto AR, et al. (2007). "The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro". Blood. 109 (11): 4806–9. doi:10.1182/blood-2006-09-047449. PMID 17311996.
Li J, Cadeiras M, Prinz von Bayern M, et al. (2007). "G6b-B cell surface inhibitory receptor expression is highly restricted to CD4+ T-cells and induced by interleukin-4-activated STAT6 pathway". Hum. Immunol. 68 (8): 708–14. doi:10.1016/j.humimm.2007.04.008. PMID 17678728.

[refGRCh38Ensembl-1] ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 GRCh38: Ensembl release 89: ENSG00000206396, ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073414 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10384126-5] Ribas G, Neville M, Wixon JL, Cheng J, Campbell RD (Jul 1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". J Immunol. 163 (1): 278–87. PMID 10384126.

[pmid11544253-6] Vet EC, Aguado B, Campbell RD (Nov 2001). "G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2". J Biol Chem. 276 (45): 42070–6. doi:10.1074/jbc.M103214200. PMID 11544253.

[entrez-7] "Entrez Gene: C6orf25 chromosome 6 open reading frame 25".

[UniProt-8] "UniProt, O95866" (jezik: engleski). Zanemaren tekst "2021-10-02" (pomoć)

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