SPSB3

Domen SPRY
Identifikatori
Simbol	SPRY

SPSB3
Identifikatori
Aliasi	SPSB3
Vanjski ID-jevi	OMIM: 611659 MGI: 1891471 HomoloGene: 12322 GeneCards: SPSB3
Lokacija gena (čovjek) Hrom. Hromosom 16 (čovjek) Bend 16p13.3 Početak 1,776,712 bp Kraj 1,793,700 bp
Lokacija gena (miš) Hrom. Hromosom 17 (miš) Bend 17|17 A3.3 Početak 25,105,617 bp Kraj 25,111,126 bp
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • GO:0050372 aktivnost sa transferazom ubikvitina Ćelijska komponenta • citosol • SCF ubiquitin ligase complex Biološki proces • protein ubiquitination • Posttranslacione modifikacije • ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	90864	79043
Ensembl	ENSG00000162032	ENSMUSG00000024160
UniProt	Q6PJ21	Q571F5
RefSeq (mRNK)	NM_080861 NM_001324081	NM_001163750 NM_001163751 NM_027141 NM_001374602 NM_001400229 NM_001400231 NM_001400234 NM_001400235 NM_001400236 NM_001400237 NM_001400238 NM_001400240
RefSeq (bjelančevina)	NP_001311010 NP_543137	NP_001157222 NP_001157223 NP_081417 NP_001361531 NP_001387158 NP_001387160 NP_001387163 NP_001387164 NP_001387165 NP_001387166 NP_001387167 NP_001387169
Lokacija (UCSC)	Chr 16: 1.78 – 1.79 Mb	Chr 17: 25.11 – 25.11 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Domen SplA/rijanodinskog receptora i protein 3 sa SOCS-om je protein koji je kod ljudi kodiran genom SPSB3.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 355 aminokiselina, a molekulska težina 39.376 Da..

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MARRPRNSRA		WHFVLSAARR		DADARAVALA		GSTNWGYDSD		GQHSDSDSDP
EYSTLPPSIP		SAVPVTGESF		CDCAGQSEAS		FCSSLHSAHR		GRDCRCGEED
EYFDWVWDDL		NKSSATLLSC		DNRKVSFHME		YSCGTAAIRG		TKELGEGQHF
WEIKMTSPVY		GTDMMVGIGT		SDVDLDKYRH		TFCSLLGRDE		DSWGLSYTGL
LHHKGDKTSF		SSRFGQGSII		GVHLDTWHGT		LTFFKNRKCI		GVAATKLQNK
RFYPMVCSTA		ARSSMKVTRS		CASATSLQYL		CCHRLRQLRP		DSGDTLEGLP
LPPGLKQVLH		NKLGWVLSMS		CSRRKAPVSD		PQAATSAHPS		SREPRPCQRK
RCRRT

Dopunska literatura

• Nishiya T, Matsumoto K, Maekawa S, Kajita E, Horinouchi T, Fujimuro M, Ogasawara K, Uehara T, Miwa S (mart 2011). "Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins". The Journal of Biological Chemistry. 286 (11): 9009–19. doi:10.1074/jbc.M110.190678. PMC 3058989. PMID 21199876.
• Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (maj 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Wang D, Li Z, Messing EM, Wu G (april 2005). "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway". The Journal of Biological Chemistry. 280 (16): 16393–401. doi:10.1074/jbc.M413897200. PMID 15713673.
• Naukkarinen J, Surakka I, Pietiläinen KH, Rissanen A, Salomaa V, Ripatti S, Yki-Järvinen H, van Duijn CM, Wichmann HE, Kaprio J, Taskinen MR, Peltonen L (juni 2010). Gibson G (ured.). "Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes". PLOS Genetics. 6 (6): e1000976. doi:10.1371/journal.pgen.1000976. PMC 2880558. PMID 20532202.
• Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (februar 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.

Vanjski linkovi

Eukaryotic Linear Motif resource motif class LIG_SPRY_1