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Preclinical imaging is the visualization of living animals for research purposes, such as drug development. Imaging modalities have long been crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level, in animals responding to physiological or environmental changes. Imaging modalities that are non-invasive and in vivo have become especially important to study animal models longitudinally. Broadly speaking, these imaging systems can be categorized into primarily morphological/anatomical and primarily molecular imaging techniques. Techniques such as high-frequency micro-ultrasound, magnetic resonance imaging (MRI) and computed tomography (CT) are usually used for anatomical imaging, while optical imaging (fluorescence and bioluminescence), positron

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rdf:type	software
rdfs:label	Preclinical imaging (en) Obrazowanie przedkliniczne (pl)
rdfs:comment	Preclinical imaging is the visualization of living animals for research purposes, such as drug development. Imaging modalities have long been crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level, in animals responding to physiological or environmental changes. Imaging modalities that are non-invasive and in vivo have become especially important to study animal models longitudinally. Broadly speaking, these imaging systems can be categorized into primarily morphological/anatomical and primarily molecular imaging techniques. Techniques such as high-frequency micro-ultrasound, magnetic resonance imaging (MRI) and computed tomography (CT) are usually used for anatomical imaging, while optical imaging (fluorescence and bioluminescence), positron (en) Obrazowanie przedkliniczne – pojęcie odnoszące się do obrazowania medycznego przeprowadzanego w fazie przedklinicznej badań eksperymentalnych. Może być przeprowadzane in vitro na komórkach i tkankach wyizolowanych z organizmów zwierząt lub in vivo na żywym organizmie. Stosuje się również odmianę in vivo nazywaną ex vivo, która od in vivo różni się tym, że materiał biologiczny jest pozyskiwany z żywego organizmu w celu jego modyfikacji in vitro i ponownego podania z powrotem do organizmu, z którego go pozyskano. W odróżnieniu od klasycznego obrazowania diagnostycznego (diagnostyki obrazowej), obrazowanie przedkliniczne skupia się głównie na wykrywaniu zaburzeń na poziomie molekularnym, które stoją u podstaw rozwoju procesów chorobowych, a nie na widocznych końcowych efektach tych procesów. (pl)
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dct:subject	Imaging Medical imaging Medical physics
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Link from a Wikipage to another Wikipage	Cancer Roger Y. Tsien CAR-T cell SPECT/CT Imaging Preclinical SPECT Computed tomography Craniotomy 18F-FDG Functional magnetic resonance imaging Functional ultrasound imaging Antibody Magnetic resonance imaging Prostate cancer Medical optical imaging Cell (biology) Larmor precession Spin quantum number Medical imaging Medical physics FMRI Fluorescence Fluorescence imaging Fluoride Fluorine-18 Angiogenesis Cardiotoxicity Biomarkers dbr:Glutamate_carboxypeptidase_II Glycoprotein IIb/IIIa Radiation Radio frequency Red blood cell Hemoglobin Technetium-99m Chimeric antigen receptor T cell Bioluminescence Radioactive tracer Hemodynamic Positron Emission Tomography Positron emission tomography Optical imaging Radiotherapy Cerebrospinal fluid Photobleaching Ultrasound research interface PET/CT Vascular endothelial growth factor receptors PET/MR Charged coupled device Photoacoustic tomography Chelating Fluorochromes 99mTC Confounding variable Single photon emission computed tomography CRISPR/Cas9-mediated genome editing Hemorrhages Γ-rays
sameAs	Preclinical imaging Preclinical imaging Preclinical imaging Preclinical imaging Preclinical imaging
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has abstract	Preclinical imaging is the visualization of living animals for research purposes, such as drug development. Imaging modalities have long been crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level, in animals responding to physiological or environmental changes. Imaging modalities that are non-invasive and in vivo have become especially important to study animal models longitudinally. Broadly speaking, these imaging systems can be categorized into primarily morphological/anatomical and primarily molecular imaging techniques. Techniques such as high-frequency micro-ultrasound, magnetic resonance imaging (MRI) and computed tomography (CT) are usually used for anatomical imaging, while optical imaging (fluorescence and bioluminescence), positron emission tomography (PET), and single photon emission computed tomography (SPECT) are usually used for molecular visualizations. These days, many manufacturers provide multi-modal systems combining the advantages of anatomical modalities such as CT and MR with the functional imaging of PET and SPECT. As in the clinical market, common combinations are SPECT/CT, PET/CT and PET/MR. (en)

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