The Lucania – Medici in Rete (LuMiR) project aims to support the shift from organization-centric to patient-centric healthcare in Basilicata, a region in the southern Italy. Main objective of the project is to foster collaborative, multidisciplinary and cross-organizational healthcare processes by developing and stimulating the adoption of a region-wide, software infrastructure, the LuMiR system. It is a suite of e-services that facilitates the sharing of patient related clinical data among authorized professionals, by enabling the interoperability among Electronic Medical. In the paper the LuMiR project approach is discussed, pointing out the methodology adopted in the design and development of the LuMiR system, the peculiarities of the system architecture and interventions scheduled to mitigate the risks related to the large scale adoption of the LuMiR system itself.