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A Prototype Stimulator System for Noninvasive Low Intensity Focused Ultrasound Delivery
Amit P. Mulgaonkar, Rahul S. Singh, Meghedi Babakhanian, Martin O. Culjat, Warren S. Grundfest, Alessandra Gorgulho, Goran Lacan, Antonio A.F. De Salles, Alexander Bystritsky, William P. Melega
A prototype Low Intensity Focused Ultrasound (LIFU) stimulator system was developed to evaluate non-invasive neuromodulation in a large animal model. We conducted a feasibility study on a Göttingen minipig, demonstrating reversible, targeted transcranial neuromodulation. The hypothalamus of the minipig was repeatedly stimulated with LIFU which evoked temporally correlated increases in both heart rate and blood pressure.
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