TSHZ3: Difference between revisions

'''Teashirt homolog 3''' is a [[protein]] that in humans is encoded by the ''TSHZ3'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TSHZ3 teashirt family zinc finger 3| url = httphttps://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57616| accessdate = }}</ref> In mice, it is a necessary part of the neural circuitry that controls breathing. The gene is also a homolog of the [[Drosophila melanogaster]] teashirt gene, which encodes a [[zinc finger]] [[transcription factor]] important for development of the trunk.<ref>{{cite journal | vauthors = Fasano L, Röder L, Coré N, Alexandre E, Vola C, Jacq B, Kerridge S | title = The gene teashirt is required for the development of Drosophila embryonic trunk segments and encodes a protein with widely spaced zinc finger motifs | journal = Cell | volume = 64 | issue = 1 | pages = 63–79 | date = January 1991 | pmid = 1846092 | doi = 10.1016/0092-8674(91)90209-h | s2cid = 39211509 }}</ref>

''Tshz3''-[[knockout mouse|knockout mice]] do not develop the respiratory rhythm generator ([[Central_pattern_generatorCentral pattern generator#Rhythm_generatorsRhythm generators|RRG]]) neural circuit, which is a pacemaker that produces an oscillating rhythm in the brainstem and controls autonomous breathing. The RRG [[neuron]]s are present, but are abnormal. Those mice do not survive because they don't initiate breathing after birth. Tshz-3''Tshz3'' is being studied for its relationship to infant breathing defects in humans.<ref name="pmid20631175">{{cite journal | authorvauthors = Caubit X, Thoby-Brisson M, Voituron N, Filippi P, Bévengut M, Faralli H, Zanella S, Fortin G, Hilaire G, Fasano L | display-authors = 6 | title = Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control | journal = J.The Neurosci.Journal of Neuroscience | volume = 30 | issue = 28 | pages = 9465–76 | yeardate = July 2010 | monthpmid = July20631175 | pmidpmc = 206311756632443 | doi = 10.1523/JNEUROSCI.1765-10.2010}}*{{lay source |template laysummary= cite web|vauthors = httpde Lange C |url = https://www.newscientist.com/article/dn19218-single-gene-could-be-key-to-a-babys-first-breath.html|title = Single gene could be key to a baby's first breath|date laysource= July 23, 2010 |website = New Scientist }}</ref>

== Further reading ==

* {{cite journal | authorvauthors = Olsen JV, Blagoev B, Gnad F, ''etMacek al.''B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 |year date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}

* {{cite journal | authorvauthors = Mehrle A, Rosenfelder H, Schupp I, ''etdel al.''Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | display-authors = 6 | title = The LIFEdb database in 2006. | journal = Nucleic Acids Res.Research | volume = 34 | issue = Database issue | pages = D415–8D415-8 |year date = January 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 | pmc=1347501 }}

* {{cite journal | authorvauthors = Wiemann S, Arlt D, Huber W, ''etWellenreuther al.''R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | display-authors = 6 | title = From ORFeome to biology: a functional genomics pipeline. | journal = Genome Res.Research | volume = 14 | issue = 10B | pages = 2136–44 |year date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 | pmc=528930 }}

* {{cite journal | authorvauthors = Brandenberger R, Wei H, Zhang S, ''etLei al.''S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | display-authors = 6 | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. | journal =Nat. Biotechnol.Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 |year date = 2005June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 | s2cid = 27764390 }}

* {{cite journal | authorvauthors =Wiemann S,Hartley Weil BJL, WellenreutherTemple RGF, ''etBrasch al.''MA | title =Toward aDNA catalogcloning ofusing humanin genesvitro andsite-specific proteins:recombination sequencing| andjournal analysis= ofGenome 500Research novel| completevolume protein= coding human cDNAs.10 |journal=Genome Res.issue |volume= 11 |issue pages = 31788–95 |pages date = 422–35November 2000 |year pmid = 200111076863 |pmid pmc = 11230166310948 | doi = 10.1101/gr.GR1547R | pmc=311072143000 }}

* {{cite journal | authorvauthors =Hartley JLNagase T, Kikuno R, Ishikawa K, TempleHirosawa GFM, BraschOhara MAO | title =DNA cloningPrediction usingof inthe vitrocoding site-specificsequences recombinationof unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal =Genome Res.DNA Research | volume =10 7 | issue = 112 | pages = 1788–95143–50 |year date = 2001April 2000 | pmid = 1107686310819331 | doi = 10.11011093/grdnares/7.143000 2.143 | pmcdoi-access =310948 free }}