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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{cs1 config|name-list-style=vanc|display-authors=6}}
{{Infobox_gene}}
'''Acyl-CoA thioesterase 2''', also known as '''ACOT2''', is an [[enzyme]] which in humans is encoded by the ''ACOT2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ACOT2 acyl-CoA thioesterase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10965|
Acyl-CoA thioesterases, such as ACOT2, are a group of enzymes that hydrolyze [[Coenzyme A]] (CoA) [[ester]]s, such as acyl-CoAs, bile CoAs, and CoA esters of prostaglandins, to the corresponding free acid and CoA.<ref name="pmid16103133">{{cite journal | vauthors = Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE | title = A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases | journal = Journal of Lipid Research | volume = 46 | issue = 9 | pages =
== Function ==
The protein encoded by the ACOT2 gene is part of a family of [[Acyl-CoA]] [[thioesterase]]s, which catalyze the [[hydrolysis]] of various [[Coenzyme A]] esters of various molecules to the free acid plus CoA. These enzymes have also been referred to in the literature as acyl-CoA hydrolases, acyl-CoA thioester hydrolases, and palmitoyl-CoA hydrolases. The reaction carried out by these [[enzyme]]s is as follows:
CoA ester + H<sub>2</sub>O → free acid + coenzyme A
These enzymes use the same [[substrate (chemistry)|substrate]]s as long-chain acyl-CoA synthetases, but have a unique purpose in that they generate the free acid and CoA, as opposed to long-chain acyl-CoA synthetases, which ligate fatty acids to CoA, to produce the CoA ester.<ref>{{cite journal |
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== References ==
{{reflist}}
==External links==▼
* {{UCSC gene info|ACOT2}}▼
* {{PDBe-KB2|P49753|Acyl-coenzyme A thioesterase 2, mitochondrial}}▼
== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
* {{cite journal | vauthors =
* {{cite journal | vauthors =
* {{cite journal | vauthors =
* {{cite journal | vauthors =
* {{cite journal | vauthors = Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH | title = Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | journal = Nature | volume = 375 | issue = 6534 | pages =
▲* {{cite journal | vauthors = Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH | title = Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | journal = Nature | volume = 375 | issue = 6534 | pages = 754–60 | date = Jun 1995 | pmid = 7596406 | doi = 10.1038/375754a0 | bibcode = 1995Natur.375..754S | s2cid = 4308372 }}
{{refend}}
▲== External links ==
▲* {{UCSC gene info|ACOT2}}
▲* {{PDBe-KB2|P49753|Acyl-coenzyme A thioesterase 2, mitochondrial}}
{{Thioesterases}}
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