ACOT2: Difference between revisions

'''Acyl-CoA thioesterase 2''', also known as '''ACOT2''', is an [[enzyme]] which in humans is encoded by the ''ACOT2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ACOT2 acyl-CoA thioesterase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10965| accessdate = }}</ref><ref name="pmid10944470">{{vcite2cite journal | vauthors = Jones JM, Gould SJ | title = Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase | journal = Biochemical and Biophysical Research Communications | volume = 275 | issue = 1 | pages = 233–40 | date = Aug 2000 | pmid = 10944470 | doi = 10.1006/bbrc.2000.3285 }}</ref><ref name="pmid16940157">{{vcite2cite journal | vauthors = Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE | title = Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs | journal = FASEB Journal | volume = 20 | issue = 11 | pages = 1855–64 | date = Sep 2006 | pmid = 16940157 | doi = 10.1096/fj.06-6042com }}</ref>

Acyl-CoA thioesterases, such as ACOT2, are a group of enzymes that hydrolyze [[Coenzyme A]] (CoA) [[ester]]s, such as acyl-CoAs, bile CoAs, and CoA esters of prostaglandins, to the corresponding free acid and CoA.<ref name="pmid16103133">{{vcite2cite journal | vauthors = Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE | title = A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases | journal = Journal of Lipid Research | volume = 46 | issue = 9 | pages = 2029–32 | date = Sep 2005 | pmid = 16103133 | doi = 10.1194/jlr.E500003-JLR200 }}</ref> ACOT2 shows high acyl-CoA [[thioesterase]] activity on medium- and long-chain acyl-CoAs, with an optimal pH of 8.5. It is most active on [[myristic acid|myristoyl]]-CoA but also shows high activity on [[palmitic acid|palmitoyl]]-CoA, [[stearic acid|stearoyl]]-CoA, and [[arachidic acid|arachidoyl]]-CoA.<ref name="pmid10944470"/>

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* {{vcite2cite journal | vauthors = Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE | title = Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs | journal = FASEB Journal | volume = 20 | issue = 11 | pages = 1855–64 | date = Sep 2006 | pmid = 16940157 | doi = 10.1096/fj.06-6042com }}

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