Revision as of 12:21, 15 September 2017 edit KolbertBot (talk \| contribs) Bots 1,166,042 edits m Bot: HTTP→HTTPS ← Previous edit		Revision as of 15:48, 31 January 2018 edit undo 139.124.8.218 (talk) Added new important information about Tshz3 function Tag: Visual edit Next edit →
Line 2: '''Teashirt homolog 3''' is a [[protein]] that in humans is encoded by the ''TSHZ3'' [[gene]].<ref name="entrez">{{cite web \| title = Entrez Gene: TSHZ3 teashirt family zinc finger 3\| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57616\| accessdate = }}</ref> In mice, it is a necessary part of the neural circuitry that controls breathing. The gene is also a homolog of the [[Drosophila melanogaster]] teashirt gene, which encodes a [[zinc finger]] [[transcription factor]] important for development of the trunk. ''Tshz3''-[[knockout mouse\|knockout mice]] do not develop the respiratory rhythm generator ([[Central pattern generator#Rhythm generators\|RRG]]) neural circuit, which is a pacemaker that produces an oscillating rhythm in the brainstem and controls autonomous breathing. The RRG [[neuron]]s are present, but are abnormal. Those mice do not survive because they don't initiate breathing after birth. ~~Tshz-3~~''Tshz3'' is being studied for its relationship to infant breathing defects in humans.<ref name="pmid20631175">{{cite journal \| vauthors = Caubit X, Thoby-Brisson M, Voituron N, Filippi P, Bévengut M, Faralli H, Zanella S, Fortin G, Hilaire G, Fasano L \| title = Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control \| journal = J. Neurosci. \| volume = 30 \| issue = 28 \| pages = 9465–76 \|date=July 2010 \| pmid = 20631175 \| doi = 10.1523/JNEUROSCI.1765-10.2010 \| laysummary = https://www.newscientist.com/article/dn19218-single-gene-could-be-key-to-a-babys-first-breath.html \| laysource = New Scientist }}</ref> Recently, ''TSHZ3'' has been identified as a critical region for a syndrome associated with heterozygous deletions at 19q12-q13.11, which includes autism spectrum disorder (ASD) symptoms such autistic traits, speech disturbance and intellectual disability, as well as renal tract abnormalities.<ref>{{Cite web\|url=https://www-ncbi-nlm-nih-gov.insb.bib.cnrs.fr/pubmed/?term=caubit+x\|title=TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.\|last=\|first=\|date=\|website=\|archive-url=\|archive-date=\|dead-url=\|access-date=}}</ref> Mice with heterozygous ''Tshz3'' deletion (''Tshz3<sup>lacZ</sup>''<sup>/+</sup>) show enrichment of ASD-related gene orthologs in the cerebral cortex, functional alterations of corticostriatal circuitry and ASD-relevant behavioral abnormalities.<ref>{{Cite web\|url=https://www-ncbi-nlm-nih-gov.insb.bib.cnrs.fr/pubmed/?term=caubit+x\|title=Login\|website=www-ncbi-nlm-nih-gov.insb.bib.cnrs.fr\|access-date=2018-01-31}}</ref> ==References==

TSHZ3: Difference between revisions