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'''Teashirt homolog 3''' is a [[protein]] that in humans is encoded by the ''TSHZ3'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TSHZ3 teashirt family zinc finger 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57616| accessdate = }}</ref> In mice, it is a necessary part of the neural circuitry that controls breathing. The gene is also a homolog of the [[Drosophila melanogaster]] teashirt gene, which encodes a [[zinc finger]] [[transcription factor]] important for development of the trunk.
''Tshz3''-[[knockout mouse|knockout mice]] do not develop the respiratory rhythm generator ([[Central pattern generator#Rhythm generators|RRG]]) neural circuit, which is a pacemaker that produces an oscillating rhythm in the brainstem and controls autonomous breathing. The RRG [[neuron]]s are present, but are abnormal. Those mice do not survive because they don't initiate breathing after birth.
Recently, ''TSHZ3'' has been identified as a critical region for a syndrome associated with heterozygous deletions at 19q12-q13.11, which includes autism spectrum disorder (ASD) symptoms such autistic traits, speech disturbance and intellectual disability, as well as renal tract abnormalities.<ref>{{Cite web|url=https://www-ncbi-nlm-nih-gov.insb.bib.cnrs.fr/pubmed/?term=caubit+x|title=TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref> Mice with heterozygous ''Tshz3'' deletion (''Tshz3<sup>lacZ</sup>''<sup>/+</sup>) show enrichment of ASD-related gene orthologs in the cerebral cortex, functional alterations of corticostriatal circuitry and ASD-relevant behavioral abnormalities.<ref>{{Cite web|url=https://www-ncbi-nlm-nih-gov.insb.bib.cnrs.fr/pubmed/?term=caubit+x|title=Login|website=www-ncbi-nlm-nih-gov.insb.bib.cnrs.fr|access-date=2018-01-31}}</ref>
==References==
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