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Vandergiezen (talk | contribs) m Added reference to original work from Cerkasovova et al for historical accuracy. |
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Hydrogenosomes were isolated, purified, biochemically characterized and named in the early 1970s by D. G. Lindmark and M. Müller at [[Rockefeller University]].<ref>{{cite journal |vauthors=Lindmark DG, Müller M |title=Hydrogenosome, a cytoplasmic organelle of the anaerobic flagellate ''Tritrichomonas foetus'', and its role in pyruvate metabolism |journal=J. Biol. Chem. |volume=248 |issue=22 |pages=7724–8 |date=November 1973 |pmid=4750424 |url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=4750424}}</ref> In addition to this seminal study on hydrogenosomes, they also demonstrated, for the first time, the presence of [[Pyruvate:ferredoxin oxidoreductase|pyruvate:ferredoxin oxido-reductase]] and [[hydrogenase]] in [[eukaryote]]s. Further studies were subsequently conducted on the biochemical [[cytology]] and [[subcellular]] organization of anaerobic [[Protozoan parasite|protozoan parasites]] (''[[Trichomonas vaginalis]], [[Tritrichomonas foetus]], Monocercomonas sp., [[Giardia lamblia]], [[Entamoeba]] sp., and Hexamita inflata)''. It is often forgotten that a Czechoslovakian group also biochemically described hydrogenosomes in 1973<ref>Čerkasovová, A., Lukasová, G., Čerkasòv, J.. Kulda, J. (1973) Biochemical Characterization of Large Granule Fraction of ''Tritrichomonae foetus'' ( strain KV1 ) J. Protozool. 20, 525.</ref>.
Using information obtained from hydrogenosomal and biochemical cytology studies these researchers determined the mode of action of [[metronidazole]] (Flagyl) in 1976. Metronidazole is today recognized as the gold standard [[
==Description==
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