Takayasu's arteritis: Difference between revisions

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Most people with Takayasu’s arteritis respond to [[steroids]] such as [[prednisone]]. The usual starting dose is approximately 1 milligram per kilogram of body weight per day (for most people, this is approximately 60 milligrams a day). Because of the significant [[Adverse effect (medicine)|side effects]] of long-term high-dose prednisone use, the starting dose is tapered over several weeks to a dose which controls symptoms while limiting the side effects of steroids.
 
Promising results are achieved with [[mycophenolate]] and [[tocilizumab]]<ref>Singh, Ambrish et al., Efficacy and Safetysafety of Tocilizumabtocilizumab in Treatmenttreatment of Takayasu Arteritisarteritis: aA Systematicsystematic Reviewreview of Randomizedrandomized Controlledcontrolled Trials,trials. Mod Rheumatol. 2020;31:1-20 doi: [https://wwwdoi.sciencedirectorg/10.com1080/science/article/pii/S156756881830374X?via%3Dihub14397595.2020.1724671 Atherosclerosis Supplements 32 (2018) 121-122]10.1080/14397595.2020.1724671] </ref>. If treatment is not kept to a high standard, long-term damage or death can occur.
 
Patients who do not respond to steroids may require revascularization, either via [[vascular bypass]] or [[Angioplasty|angioplasty and stenting]]. Outcomes following revascularization vary depending on the severity of the underlying disease. <ref>{{cite journal|last1=Ishikawa|first1=K|last2=Maetani|first2=S|title=Long-term outcome for 120 Japanese patients with Takayasu's disease. Clinical and statistical analyses of related prognostic factors.|journal=Circulation|date=October 1994|volume=90|issue=4|pages=1855–60|pmid=7923672|doi=10.1161/01.cir.90.4.1855}}</ref>