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{{Short description|Combination drug}}
{{Orphan|date=June 2018}}
{{Use dmy dates|date=April 2022}}
{{Infobox drug
| drug_name =
| type = combo


<!-- Combo data -->
'''Glyburide/metformin''' (trade name '''Glucovance''') is an [[anti-diabetic drug]], being a [[combination drug]] of [[glyburide]] (a [[sulfonylureas]]) and [[metformin]].
| component1 = Glibenclamide
| class1 = [[Sulfonylurea]]
| component2 = Metformin
| class2 = [[Biguanide]]


<!-- Clinical data -->
⚫
==External links==
| pronounce =
{{Portal|Pharmacy and Pharmacology}}
| tradename = Glucovance
{{Commons category|Glyburide metformin}}
| Drugs.com = {{drugs.com|monograph|glyburide}}
*[https://www.drugs.com/pro/glyburide-and-metformin.html Glucovance Uses, Dosage & Side Effects - Drugs.com]
| MedlinePlus = a699055
| DailyMedID = Glyburide_and_metformin_hydrochloride
| pregnancy_AU = C
| pregnancy_AU_comment = <ref name="Glucovance AU PI">{{cite web | url=http://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-05582-3 | title=TGA eBS - Product and Consumer Medicine Information Licence | access-date=30 April 2022 | archive-date=23 March 2022 | archive-url=https://web.archive.org/web/20220323183338/https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-05582-3 | url-status=live }}</ref>
| pregnancy_category=
| routes_of_administration = [[Oral administration|By mouth]]
| ATCvet =
| ATC_prefix = None
| ATC_suffix =
| ATC_supplemental =


<!-- Legal status -->
⚫
{{DEFAULTSORT:Glyburide metformin}}
| legal_AU = S4
⚫
[[Category:Combination drugs]]
| legal_AU_comment = <ref name="Glucovance AU PI" /><ref>{{cite web | url=https://tga-search.clients.funnelback.com/s/search.html?collection=tga-artg&profile=record&meta_i=96725 | title=Search the TGA website }}</ref><ref>{{cite web | url=https://search.tga.gov.au/s/search.html?collection=tga-artg&profile=record&meta_i=96729 | title=Search the TGA website }}</ref><ref>{{cite web | url=https://search.tga.gov.au/s/search.html?collection=tga-artg&profile=record&meta_i=96728 | title=Search the TGA website | access-date=30 April 2022 | archive-date=30 April 2022 | archive-url=https://web.archive.org/web/20220430182811/https://search.tga.gov.au/s/search.html?collection=tga-artg&profile=record&meta_i=96728 | url-status=live }}</ref>
| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F -->
| legal_BR_comment =
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment =
| legal_DE = <!-- Anlage I, II, III or Unscheduled -->
| legal_DE_comment =
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment =
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
| legal_UK_comment =
| legal_US = Rx-only
| legal_US_comment = <ref name="Glucovance FDA label">{{cite web | title=Glucovance- glyburide and metformin hydrochloride tablet, film coated | website=DailyMed | date=23 April 2012 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ff281ebd-29c2-4852-a8ab-c4f21abe8b7c | access-date=30 April 2022 | archive-date=30 April 2022 | archive-url=https://web.archive.org/web/20220430182810/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ff281ebd-29c2-4852-a8ab-c4f21abe8b7c | url-status=live }}</ref>
| legal_EU =
| legal_EU_comment =
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV -->
| legal_UN_comment =
| legal_status = <!-- For countries not listed above -->

<!-- Identifiers -->
| CAS_number = 338752-31-1
| CAS_supplemental =
| PubChem =
| IUPHAR_ligand =
| DrugBank =
| ChemSpiderID =
| UNII =
| KEGG = D10266
| ChEBI =
| ChEMBL =
| synonyms =
}}

'''Glibenclamide/metformin''', also known as glyburide/metformin and sold under the brand name '''Glucovance''', is a [[combination drug|fixed-dose combination]] [[anti-diabetic medication]] used to treat [[type 2 diabetes]].<ref name="Lamos_2012">{{cite journal | vauthors = Lamos EM, Stein SA, Davis SN | title = Combination of glibenclamide-metformin HCl for the treatment of type 2 diabetes mellitus | journal = Expert Opinion on Pharmacotherapy | volume = 13 | issue = 17 | pages = 2545–54 | date = December 2012 | pmid = 23116560 | doi = 10.1517/14656566.2012.738196 | s2cid = 10305382 }}</ref> It contains [[glibenclamide]], a [[sulfonylureas]], and [[metformin]], a [[biguanide]].<ref>{{cite web | title=Glyburide and metformin hydrochloride tablet | website=DailyMed | date=10 June 2020 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2239742b-74e1-4bc2-b5a8-15c4758d6f7b | access-date=11 August 2020 | archive-date=26 February 2021 | archive-url=https://web.archive.org/web/20210226162828/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2239742b-74e1-4bc2-b5a8-15c4758d6f7b | url-status=live }}</ref>

==References==
{{reflist}}

⚫
== External links ==
* {{cite web | url = https://druginfo.nlm.nih.gov/drugportal/name/glyburide%20mixture%20with%20metformin%20hydrochloride | publisher = U.S. National Library of Medicine | work = Drug Information Portal | title = Glyburide mixture with Metformin hydrochloride }}

{{Oral hypoglycemics}}
{{Portal bar | Medicine}}

⚫
{{DEFAULTSORT:Glibenclamide Metformin}}
[[Category:Drugs developed by Bristol Myers Squibb]]
⚫
[[Category:Combination diabetes drugs]]




Latest revision as of 15:46, 7 June 2024

Glibenclamide/metformin
Combination of
GlibenclamideSulfonylurea
MetforminBiguanide
Clinical data
Trade namesGlucovance
AHFS/Drugs.comMonograph
MedlinePlusa699055
License data
Pregnancy
category
Routes of
administration		By mouth
ATC code
  • None
Legal status
Legal status
Identifiers
CAS Number
KEGG

Glibenclamide/metformin, also known as glyburide/metformin and sold under the brand name Glucovance, is a fixed-dose combination anti-diabetic medication used to treat type 2 diabetes.[6] It contains glibenclamide, a sulfonylureas, and metformin, a biguanide.[7]

References

[edit]
  1. ^ a b "TGA eBS - Product and Consumer Medicine Information Licence". Archived from the original on 23 March 2022. Retrieved 30 April 2022.
  2. ^ "Search the TGA website".
  3. ^ "Search the TGA website".
  4. ^ "Search the TGA website". Archived from the original on 30 April 2022. Retrieved 30 April 2022.
  5. ^ "Glucovance- glyburide and metformin hydrochloride tablet, film coated". DailyMed. 23 April 2012. Archived from the original on 30 April 2022. Retrieved 30 April 2022.
  6. ^ Lamos EM, Stein SA, Davis SN (December 2012). "Combination of glibenclamide-metformin HCl for the treatment of type 2 diabetes mellitus". Expert Opinion on Pharmacotherapy. 13 (17): 2545–54. doi:10.1517/14656566.2012.738196. PMID 23116560. S2CID 10305382.
  7. ^ "Glyburide and metformin hydrochloride tablet". DailyMed. 10 June 2020. Archived from the original on 26 February 2021. Retrieved 11 August 2020.
[edit]


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