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humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins which span the cell’s membrane...35 KB (4,041 words) - 17:11, 23 December 2023
closely to alveolar epithelial cells, thus inducing the expression of the αvβ6 integrin. Integrins are dimeric cell-surface receptors composed of alpha...33 KB (3,862 words) - 13:31, 14 October 2024
active TGF-β1 and the second model is by a protease-dependent mechanism. αVβ6 integrin was the first integrin to be identified as TGF-β1 activator. LAPs...70 KB (8,486 words) - 02:10, 19 August 2024
cellular β1 integrins. Then, viral protein gH/gL interacts with cellular αvβ6/αvβ8 integrins. This triggers fusion of the viral envelope with the epithelial...62 KB (6,400 words) - 11:47, 17 October 2024
fibroblasts, epithelial cells vitronectin, osteopontin, and adenovirus αVβ6 proliferating epithelia, esp. lung and mammary gland fibronectin; TGFβ1+3...36 KB (3,929 words) - 18:22, 21 September 2024- widespread, esp. fibroblasts, epithelial cells vitronectin and adenovirus αVβ6 proliferating epithelia, esp. lung and mammary gland fibronectin; TGFβ1+3...8 KB (767 words) - 09:34, 21 September 2024
- receptor-bound gD activity Discovered that HSV utilizes gH/gL receptors, αvβ6- and αvβ8-intergins Discovered gD receptor, nectin1 to be HSV's receptor...17 KB (1,624 words) - 19:34, 16 February 2023
Major uses References RGD(S) Fibronectin α3β1, α5β1, α8β1, αvβ1, αvβ3, αvβ5, αvβ6, αIIbβ3 Promotes cell adhesion, targets tumors, used for drug discovery ...36 KB (3,744 words) - 15:44, 15 March 2024- protease-dependent mechanism. Conformation change mechanism pathway (without proteolysis) αVβ6 integrin was the first integrin to be identified as TGF-β1 activator. LAPs...20 KB (2,419 words) - 09:58, 28 June 2024
- receptor for Parechovirus B on the outer membrane of a cell called integrin αvβ6. The viral Protein RGD is what binds the virus to the cell it is trying to...12 KB (1,219 words) - 08:24, 26 July 2023
and proliferation. In contrast, when these same cells use either α9β1 or αvβ6 integrins to adhere to the same third FN type III repeat, cell spreading...20 KB (2,565 words) - 04:57, 23 December 2023- researchers postulate that this could be due to increased expression of αvβ6 integrin in tumors. Based on the positive results of the Phase I trial, an...9 KB (974 words) - 19:52, 20 December 2023
- presence of function. The activation of TGFβ via αvβ6 is related to lung and skin immune response. αvβ6 expression is found overwhelmingly in epithelial
