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- humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins which span the cell’s membrane...35 KB (4,041 words) - 17:11, 23 December 2023
- closely to alveolar epithelial cells, thus inducing the expression of the αvβ6 integrin. Integrins are dimeric cell-surface receptors composed of alpha...33 KB (3,862 words) - 13:31, 14 October 2024
- active TGF-β1 and the second model is by a protease-dependent mechanism. αVβ6 integrin was the first integrin to be identified as TGF-β1 activator. LAPs...70 KB (8,486 words) - 02:10, 19 August 2024
- cellular β1 integrins. Then, viral protein gH/gL interacts with cellular αvβ6/αvβ8 integrins. This triggers fusion of the viral envelope with the epithelial...62 KB (6,400 words) - 11:47, 17 October 2024
- fibroblasts, epithelial cells vitronectin, osteopontin, and adenovirus αVβ6 proliferating epithelia, esp. lung and mammary gland fibronectin; TGFβ1+3...36 KB (3,929 words) - 18:22, 21 September 2024
- widespread, esp. fibroblasts, epithelial cells vitronectin and adenovirus αVβ6 proliferating epithelia, esp. lung and mammary gland fibronectin; TGFβ1+3...8 KB (767 words) - 09:34, 21 September 2024
- receptor-bound gD activity Discovered that HSV utilizes gH/gL receptors, αvβ6- and αvβ8-intergins Discovered gD receptor, nectin1 to be HSV's receptor...17 KB (1,624 words) - 19:34, 16 February 2023
- Major uses References RGD(S) Fibronectin α3β1, α5β1, α8β1, αvβ1, αvβ3, αvβ5, αvβ6, αIIbβ3 Promotes cell adhesion, targets tumors, used for drug discovery ...36 KB (3,744 words) - 15:44, 15 March 2024
- protease-dependent mechanism. Conformation change mechanism pathway (without proteolysis) αVβ6 integrin was the first integrin to be identified as TGF-β1 activator. LAPs...20 KB (2,419 words) - 09:58, 28 June 2024
- receptor for Parechovirus B on the outer membrane of a cell called integrin αvβ6. The viral Protein RGD is what binds the virus to the cell it is trying to...12 KB (1,219 words) - 08:24, 26 July 2023
- and proliferation. In contrast, when these same cells use either α9β1 or αvβ6 integrins to adhere to the same third FN type III repeat, cell spreading...20 KB (2,565 words) - 04:57, 23 December 2023
- researchers postulate that this could be due to increased expression of αvβ6 integrin in tumors. Based on the positive results of the Phase I trial, an...9 KB (974 words) - 19:52, 20 December 2023
- presence of function. The activation of TGFβ via αvβ6 is related to lung and skin immune response. αvβ6 expression is found overwhelmingly in epithelial