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Oregon National Primate Research Center

Coordinates: 45°31′26″N 122°52′29″W / 45.524006°N 122.874824°W / 45.524006; -122.874824
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Oregon National Primate Research Center
Logo of the Oregon National Primate Research Center
Aerial view (2000)
Motto
"Better Health Through Scientific Discovery"
Established1962
Research typeBiomedical on nonhuman primates
DirectorNancy Haigwood
Staff230
LocationHillsboro, Oregon, United States
45°31′26″N 122°52′29″W / 45.524006°N 122.874824°W / 45.524006; -122.874824 [1]
Campus350 acres (1.4 km2)
Operating agency
Oregon Health & Science University
Websitewww.ohsu.edu

The Oregon National Primate Research Center (ONPRC) is one of seven federally funded National Primate Research Centers[2] in the United States and has been affiliated with Oregon Health and Science University (OHSU) since 1998.[3] The center is located on 200 acres (0.81 km2) of land in Hillsboro, Oregon.[4] Originally known as the Oregon Regional Primate Research Center (ORPRC), it was the first of the original seven primate centers established by the National Institutes of Health (NIH). The research center is administered and funded by the National Center for Research Resources, receiving $11 million in federal grants annually.[5]

The center maintains a colony of 4,200 non-human primates (consisting of rhesus monkeys, Japanese macaques, vervets, baboons and cynomolgus macaques),[6] cared for by 12 veterinarians and 100 full-time technicians.[7] Living conditions at the facility are inspected bi-annually by the USDA in unannounced visits. Animal rights activists have criticized the practice.

The primates are used in pure and applied biomedical research into fertility control, early embryo development, obesity, brain development and degeneration, and newly emerging viruses, especially AIDS-related agents.[8] Research projects at the facility have produced some notable findings, such as the first successful cloning of primate embryos and extraction of stem cells, which was named the number one scientific achievement of 2007 by Time.

History

Construction of the facility began in 1961 after a $1.9 million grant from the National Institutes of Health.[9] It was built on 240 acres (0.97 km2) in Washington County and opened in 1962.[9] In 1970, the Oregon location became the first of the regional centers to build and use outdoor breeding facilities.[10] By 1976 the campus housed 18 different species and 2,100 total animals while employing 225 people.[9]

In 1988, the center added the Cooley Center for Cell and Molecular Biology to the campus, followed by the Animal Services Building in 1992. OHSU took over in 1998 when the center was merged into the university.[10] In 2002, the center was renamed from the Oregon Regional Primate Center to the current name after the NIH changes the designation of all the primate research centers.[10]

Research

Scientists at the Oregon National Primate Research Center have published several research projects which have a made significant impact on health sciences.

Cloning and embryonic stem cells

In 2007, ONPRC scientists were the first to utilize cloning to reproduce primate embryos, and then extract embryonic stem cells — a procedure only previously performed in rodents, and which garnered expectations of being reproduced in humans.[11] This breakthrough was named the number one scientific achievement of the year by Time magazine.[12] In 2011, the center cloned chimeric monkeys using stem cells from six different monkeys, also a first.[13]

Multiple sclerosis

Researchers have identified factors that prevent the repair of brain damage caused by multiple sclerosis, complications of premature birth, and other diseases;[14] as well as a key gene that impacts the timing of puberty and can shorten the time span for reproduction.[15]

AIDS

Recent publications have suggested that a component of the immune system damaged by AIDS might be replaceable,[16] and have indicated a way to detect intra-amniotic infections in non-human primates, which may result in the development of a test for infections that cause premature birth in humans.[17]

Obesity

Findings in the area of obesity research include the role of the hormone leptin in causing/preventing obesity, how leptin resistance occurs and can be reversed,[18] how a high-fat diet during pregnancy affects the foetus,[19] how the natural hormone PYY can cause limited weight loss,[20] and how reduced caloric intake may slow aging and weakening of the immune system.[21]

Incidents and controversy

2010-2014

In June 2013, 21 macaques were injured and 6 macaques were killed or were euthanized when fighting broke out among a group of 260 macaques who were being housed together. Staff believed that fighting broke out due to loud noises from construction near the macaques' housing.[22][23]

In June 2013, the USDA reported several health and facility problems at the ONPRC. First, they reported that more than 50% of rhesus macaques had significant hair loss. Staff at the ONPRC did not know why it was occurring. The USDA also reported dirty and soiled bedding in some of the primate housing areas, as well as muddy areas in some of the outdoor housing areas. Additionally, the USDA reported cracked walls and defects in floor coating in some of the indoor housing areas, which made it difficult to clean and disinfect.[22][23]

In 2014, the USDA reported that a macaque was killed during an imaging procedure after the staff accidentally left a valve closed on the anesthesia machine.[22][23]

In February 2014, two animals suffered burns from an electric heating pad which was used during a procedure. The burns on one animal were so bad that the animal required surgery.[24]

2015-2019

In March 2015, the USDA reported that staff did not follow appropriate protocols when injecting a macaque with an experimental substance, which resulted in lesions to the macaque's skin. The staff made several breaches of protocol by giving the macaque six injections rather than the approved single injection, not shaving the injection site, and not notifying veterinary staff and the IACUC within the required 72 hours after the injection.[25]

In January 2016, the USDA reported that during 2015 an animal died after being entrapped in a chain in its enclosure. The chain was part of an enrichment device with an obsolete design.[26][23]

In February 2017, the USDA reported that two animals were harmed and one of which had to be euthanized after staff accidentally used a tuberculin syringe rather an insulin syringe to inject the animals with insulin.[27]

In February 2017, the USDA reported that a baboon broke its hand, which has likely due to a heavy guillotine door. The USDA also made note of excessive cobwebs and dust in some of the animal areas, which create both health risks and fire risks.[27]

In February 2018, the USDA reported that a primate was erroneously assigned to a surgical procedure despite being restricted from involvement in any more surgeries. The primate had been given a C-section in one produce and an embryo transfer in another procedure.[28]

In February 2018, the USDA reported a primate's tail was caught in a gap between two enclosures which resulted in a degloving injury and for which the staff then amputated the tail.[28]

In February 2018, the USDA reported that a juvenile primate died after getting trapped behind a wall-hung cage.[28]

In February 2018, a primate was not given buprenorphine (used to alleviate pain) or cefazolin (used to treat infections) after surgery, which was part of the approved protocol.[29]

In May 2018, a young primate was trapped in PVC pipes of a resting perch. The primate was treated by veterinarians but was later euthanized after its condition deteriorated.[29]

In July 2018, the USDA reported that two primates died after their anesthesia was inadequately monitored during surgery.[30]

In July 2018, the USDA reported that marmosets were not given water as required by an IACUC-approved protocol.[30]

2020-present

In January 2020, a juvenile macaque was trapped under a steel trough drain cover after a technician had not properly secured the cover.[31]

In August 2020, two macaques were killed when a technician accidentally put their cage, with the macaques inside, into an automatic cage washer.[31][23][32]

In October 2020, two macaques managed to escape from their cages and injured five other macaques, who were in their cages.[31]

In October 2021, two macaques were injured after the barrier between their cages malfunctioned, which allowed the macaques to access each other. The macaques fought and sustained injuries which took several days to heal.[33]

Animal care oversight

The center receives unannounced bi-annual inspections by the United States Department of Agriculture.[34] It has been accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International[35] since 1975. As required by the Animal Welfare Act, the center also maintains an Institutional Animal Care and Use Committee; each IACUC must consist of at least one veterinarian with training in laboratory animal science and expertise in the species under consideration, at least one practicing research scientist, and at least one person not affiliated with the institution to represent community interests in proper care and use of animals.

Animal rights groups

In 2000, animal rights activist Matt Rossell posed as a laboratory technician and later released video footage he had taken from inside the center. He accused them of violating federal laws and ignoring signs of distress among the rhesus monkeys housed there. "OHSU responded that Rossell's motives were suspect and his videotapes misleading."[36] The USDA concluded that the allegations were unfounded.[37]

In 2007, People for the Ethical Treatment of Animals (PETA) filed a complaint with the federal government after one of their members obtained a job at the primate center for day to day animal care and was able to take video and photos. A center spokesman said the behavior of the monkeys seen in the footage was attributable to the infiltrator entering into and creating an unfamiliar environment for the animals.[38]

See also

References

  1. ^ "University of Oregon Medical School Primate Center". Geographic Names Information System. United States Geological Survey, United States Department of the Interior. March 1, 1994. Retrieved March 22, 2010.
  2. ^ "National Primate Research Centers". National Institutes of Health. 2006. Archived from the original (webpage) on October 4, 2006. Retrieved December 4, 2006.
  3. ^ "About ONPRC: History at a Glance". Oregon Health Sciences University. 2006. Archived from the original (webpage) on October 20, 2006. Retrieved December 4, 2006.
  4. ^ "OHSU: News Release". Archived from the original on August 5, 2012.
  5. ^ Sabatier, Julie. Monkey Business Archived June 6, 2007, at the Wayback Machine, Willamette Week, December 13, 2006
  6. ^ "Caring for our Animals:Our primates". Oregon Health Sciences University. 2006. Archived from the original (webpage) on October 20, 2006. Retrieved December 4, 2006.
  7. ^ Caring for our animals Archived August 20, 2020, at the Wayback Machine, ONPRC.
  8. ^ "About ONPRC: Mission". Oregon Health Sciences University. 2006. Archived from the original (webpage) on October 20, 2006. Retrieved December 4, 2006.
  9. ^ a b c "Historic Potpourri: Primate site offers areas for research". Hillsboro Argus. October 19, 1976. p. 9.
  10. ^ a b c About ONPRC: History at a Glance Archived 2006-10-20 at archive.today
  11. ^ Kolata, Gina (November 15, 2007). "Scientists Use Monkey Clones to Extract Stem Cells". The New York Times. Archived from the original on December 25, 2014. Retrieved February 22, 2017.
  12. ^ Mahr, Krista (December 9, 2007). "Top 10 Scientific Discoveries". Time. Archived from the original on October 25, 2008. Retrieved October 20, 2008.
  13. ^ Rojas-Burke, Joe (January 5, 2012). "Oregon monkeys with six parents push the limits of embryonic stem cells". The Oregonian. Archived from the original on January 9, 2012. Retrieved January 7, 2012.
  14. ^ Back, SA; Tuohy, TM; Chen, H; Wallingford, N; Craig, A; Struve, J; Luo, NL; Banine, F; et al. (September 2005). "Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation". Nat Med. 11 (9): 966–72. doi:10.1038/nm1279. PMID 16086023. S2CID 6945872.
  15. ^ Ojeda SR, Roth C, Mungenast A, et al. (February 2006). "Neuroendocrine mechanisms controlling female puberty: new approaches, new concepts". Int. J. Androl. 29 (1): 256–63, discussion 286–90. doi:10.1111/j.1365-2605.2005.00619.x. hdl:2268/76210. PMID 16466547.
  16. ^ Picker, LJ; Reed-Inderbitzin, EF; Hagen, SI; Edgar, JB; Hansen, SG; Legasse, A; Planer, S; Piatak Jr, M; et al. (June 2006). "IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates". J Clin Invest. 116 (6): 1514–24. doi:10.1172/JCI27564. PMC 1459071. PMID 16691294. Archived from the original on September 27, 2007.
  17. ^ Gravett, MG; Novy, MJ; Rosenfeld, RG; Reddy, AP; Jacob, T; Turner, M; McCormack, A; Lapidus, JA; et al. (July 28, 2004). "Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers". JAMA. 292 (4): 462–9. doi:10.1001/jama.292.4.462. PMID 15280344.
    "Erratum". JAMA. 292 (19): 2340. November 2004. doi:10.1001/jama.292.19.2340.
  18. ^ Bouret, SG; Draper, SJ; Simerly, RB (April 2, 2004). "Trophic action of leptin on hypothalamic neurons that regulate feeding". Science. 304 (5667): 108–10. Bibcode:2004Sci...304..108B. doi:10.1126/science.1095004. PMID 15064420. S2CID 39947532.
  19. ^ Grayson BE, Allen SE, Billes SK, Williams SM, Smith MS, Grove KL (December 2006). "Prenatal development of hypothalamic neuropeptide systems in the nonhuman primate". Neuroscience. 143 (4): 975–86. doi:10.1016/j.neuroscience.2006.08.055. PMID 17029798. S2CID 22101163.
  20. ^ Batterham, RL; Cowley, MA; Small, CJ; Herzog, H; Cohen, MA; Dakin, CL; Wren, AM; Brynes, AE; et al. (2002). "Gut hormone PYY3-36 physiologically inhibits food intake". Nature. 418 (6898): 650–4. Bibcode:2002Natur.418..650B. doi:10.1038/nature00887. PMID 12167864. S2CID 4300829.
  21. ^ Messaoudi, I; Warner, J; Fischer, M; Park, B; Hill, B; Mattison, J; Lane, MA; Roth, GS; et al. (December 19, 2006). "Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates". Proc Natl Acad Sci U S A. 103 (51): 19448–53. doi:10.1073/pnas.0606661103. PMC 1748246. PMID 17159149.
  22. ^ a b c Hallberg, Gwynn (April 2, 2014). "USDA Inspection Report 97141843570379". USDA. Retrieved March 21, 2022.
  23. ^ a b c d e Vaughn, Courtney (December 14, 2021). "As lab animal mishaps mount, advocacy groups say Oregon is worst offender". Beaverton Valley Times. Retrieved March 23, 2022.
  24. ^ Hallberg, Gwynn (July 29, 2014). "USDA Inspection Report 213141735510203". USDA. Retrieved March 21, 2022.
  25. ^ Hallberg, Gwynn (March 24, 2015). "USDA Inspection Report 89151954210841". USDA. Retrieved March 21, 2022.
  26. ^ Hallberg, Gwynn (January 14, 2016). "USDA Inspection Report 19161835430912". USDA. Retrieved March 21, 2022.
  27. ^ a b Hallberg, Gwynn (February 14, 2017). "USDA Inspection Report 2016082568108354". USDA. Retrieved March 21, 2022.
  28. ^ a b c Hallberg, Gwynn (February 5, 2018). "USDA Inspection Report 2016082569072176". USDA. Retrieved March 21, 2022.
  29. ^ a b Schnell, Michael (August 6, 2018). "USDA Inspection Report 2016082569239077". USDA. Retrieved March 21, 2022.
  30. ^ a b Hallberg, Gwynn (July 19, 2018). "USDA Inspection Report 2016082569222604". USDA. Retrieved March 21, 2022.
  31. ^ a b c Hallberg, Gwynn (January 25, 2021). "USDA Inspection Report 2016090000523752". USDA. Retrieved March 23, 2022.
  32. ^ Rambo, K. (August 29, 2020). "Two monkeys die in 'tragic accident' at controversial OHSU primate research facility". The Oregonian. Retrieved March 23, 2022.
  33. ^ Hallberg, Gwynn (February 8, 2022). "USDA Inspection Report 2016090000767970". USDA. Retrieved March 23, 2022.
  34. ^ "United States Department of Agriculture". Archived from the original on July 31, 2007. Retrieved August 22, 2007.
  35. ^ "Association for Assessment and Accreditation of Laboratory Animal Care International". Archived from the original on February 23, 2009. Retrieved August 22, 2007.
  36. ^ Dawdy, Philip (January 3, 2001). "Shock the Monkeys". Willamette Week. Archived from the original on March 9, 2001.
  37. ^ "USDA Finishes Report on Oregon Regional Primate Research Center, Concludes allegations are unfounded. OHSU News Release, January 12, 2001". Archived from the original on August 5, 2012.
  38. ^ Savickas, Daniel (November 13, 2008). "PETA files complaint against Oregon National Primate Research Center". Portland Tribune. Archived from the original on June 8, 2011.
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