Ethacridine lactate: Difference between revisions

{{Short description|Pair of enantiomers}}

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 477162867

| IUPAC_name = 7-Ethoxyacridine-3,9-diamine 2-hydroxypropanoic acid

| image = Ethacridinlactat.svg

| alt = Skeletal formulas of ethacridine lactate

| image2 = Ethacridine lactate 3D spacefill.png

| alt2 = Ball-and-stick models of the component ions of ethacridine lactate

<!--Clinical data-->

| tradename =

| Drugs.com = {{drugs.com|international|ethacridine-lactate}}

| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->

| pregnancy_US = <!-- A / B / C / D / X -->

| pregnancy_category =

| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->

| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->

| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->

| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->

| legal_status =

| routes_of_administration =

<!--Pharmacokinetic data-->

| bioavailability =

| protein_bound =

| metabolism =

| elimination_half-life =

| excretion =

<!--Identifiers-->

| CAS_number_Ref = {{cascite|changed|??}}

| CAS_number = 1837-57-6

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 7T7T2I9823

| ATCvet =

| ATC_prefix = B05

| ATC_suffix = CA08

| ATC_supplemental = {{ATC|D08|AA01}}

| PubChem = 15789

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| DrugBank =

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = D01248

| ChEMBL_Ref = {{ebicite|correct|EBI}}

| ChEMBL = 582355

<!--Chemical data-->

| C=18 | H=21 | N=3 | O=4

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

'''Ethacridine lactate''' (ethacridine monolactate monohydrate, '''acrinol''', [[trade name]] '''Rivanol''') is an [[aromatic]] [[organic compound]] based on [[acridine]]. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.

Its primary use is as an [[antiseptic]]<ref>Merck Index, 11th Ed., 3668</ref> in solutions of 0.1%. It is effective against mostly [[Gram-positive bacteria]], such as ''[[Streptococci]]'' and ''[[Staphylococci]]'', but ineffective against [[Gram-negative bacteria]] such as ''[[Pseudomonas aeruginosa]]''.<ref>{{cite journal |vauthors=Adarchenko AA, Krasil'nikov AP, Sobeshchuk OP |title=[Antiseptic sensitivity of clinical strains of Pseudomonas aeruginosa] |language=Russian |journal=Antibiotiki I Khimioterapiia |volume=34 |issue=12 |pages=902–7 |year=1989 |pmid=2517004 }}</ref>

Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a [[foley catheter]]. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used.<ref>{{Cite journal

| last1 = Tien | first1 = K. H.

| title = Intraamniotic injection of ethacridine for second-trimester induction of labor

| journal = Obstetrics and Gynecology

| volume = 61

| issue = 6

| pages = 733–736

| year = 1983

| pmid = 6843933

}}</ref> Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.

{{reflist}}

{{Blood substitutes and perfusion solutions}}

[[Category:Ethoxy compounds]]