Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and Tobramycin/dexamethasone: Difference between pages

{{Short description|Pharmaceutical preparation}}

| Verifiedfields = changed

| verifiedrevid = 477865033

| type = combo

| tradename = Tobradex

| Drugs.com = {{drugs.com|ppa|tobramycin-and-dexamethasone}}

| pregnancy_US_comment = <ref name="Drugs.com pregnancy">{{cite web | title=Dexamethasone / tobramycin ophthalmic Use During Pregnancy | website=Drugs.com | date=28 November 2018 | url=https://www.drugs.com/pregnancy/dexamethasone-tobramycin-ophthalmic.html | access-date=13 September 2020}}</ref>

| routes_of_administration = [[Ophthalmic administration|Eye drops]], [[Topical medication|topical]]

| ATCvet =

| ATC_prefix = S01

| ATC_suffix = CA01

| legal_US_comment = <ref name="Tobradex ointment FDA label" /><ref name="Tobradex drops FDA label" /><ref name="Tobradex ST FDA label" />

| CAS_number_Ref = {{cascite|correct|CAS}}

| CAS_number2_Ref = {{cascite|correct|CAS}}

| CAS_number2 = 50-02-2

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = 10123949

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = VZ8RRZ51VK

| UNII2_Ref = {{fdacite|correct|FDA}}

| UNII2 = 7S5I7G3JQL

| KEGG_Ref = {{keggcite|changed|kegg}}

| KEGG = D11178

| ChEBI_Ref = {{ebicite|correct|EBI}}

| ChEBI = 28864

| ChEMBL_Ref = {{ebicite|correct|EBI}}

| ChEMBL = 1747

'''Tobramycin/dexamethasone''', sold under the brand name '''Tobradex''', is a fixed-dose [[combination medication]] in the form of [[eye drops]] and eye [[ointment]], marketed by [[Alcon]].<ref name="Tobradex ointment FDA label" /><ref name="Tobradex drops FDA label" /><ref name="Tobradex ST FDA label" /> The active ingredients are [[tobramycin]] (an [[antibiotic]]) and [[dexamethasone]] (a [[corticosteroid]]).<ref name="Tobradex drops FDA label" /> It is prescribed for the treatment of [[conjunctivitis|pink eye]] in combination with bacterial infections.<ref name="Tobradex drops FDA label" />

== Contraindications ==

It is contraindicated with [[Herpetic infection|herpetic]] and other [[viral infection|viral]] eye infections. Other contraindications include [[Mycosis|fungal]] and [[mycobacteria]]l infections because tobramycin is inactive against those, and the corticoid acts as an [[immunosuppressive]] agent, preventing the body's immune system from dealing with the infection. The drops are also contraindicated in patients with [[cornea]]l lesions.<ref name="AustriaCodex">{{cite book|title=Austria-Codex|at=Tobradex-Augentropfen| veditors = Haberfeld H |publisher=Österreichischer Apothekerverlag|location=Vienna|year=2009|edition=2009/2010|isbn=978-3-85200-196-8|language=German}}</ref><ref name="Tobradex ointment FDA label">{{cite web | title=Tobradex- tobramycin and dexamethasone ointment | website=DailyMed | date=24 April 2020 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5538d748-215c-4e3e-b940-ac9baf07d8a1 | access-date=24 September 2020}}</ref><ref name="Tobradex drops FDA label">{{cite web | title=Tobradex- tobramycin and dexamethasone suspension/ drops | website=DailyMed | date=24 April 2020 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=22b59456-d26a-4f23-b052-3d73e00181eb | access-date=24 September 2020}}</ref><ref name="Tobradex ST FDA label">{{cite web | title=Tobradex ST- tobramycin / dexamethasone suspension/ drops | website=DailyMed | date=9 September 2019 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d1d48422-8cfc-4e9e-a7f8-56c274d8eb83 | access-date=24 September 2020}}</ref>

== Side effects ==

Similarly to other corticosteroid eye drops, [[side effect]]s include [[hypersensitivity]] and, especially after long-term use, secondary eye infections, [[cataract]] (clouding of the eye lens) and increased [[intraocular pressure]], leading to [[glaucoma]]. Consequently, the drug should not be applied longer than 24 days<ref name="AustriaCodex"/><ref name="ÖAZ">{{cite journal | vauthors = Faschinger C | date = 3 January 2011 | journal = Österreichische Apothekerzeitung | title = TobraDex | issue = 1/2011 | pages = 13 | language = German }}</ref><ref name="Arzneistoff-Profile">{{cite book|title=Arzneistoff-Profile| veditors = Dinnendahl V, Fricke U |publisher=Govi Pharmazeutischer Verlag|location=Eschborn, Germany|year=2010|edition=23|volume=2|isbn=978-3-7741-9846-3|language=German}}

</ref> without further medical evaluation.<ref name="Tobradex drops FDA label" /><ref name="Tobradex ST FDA label" />

==Interactions==

[[Anticholinergic]] eye drops potentiate the risk of increased intraocular pressure. Systemic [[aminoglycoside antibiotic]]s increase toxicity for ears, nerves and kidney.<ref name="AustriaCodex" />

== Brand names ==

Tobrason is a brand name in Jordan.<ref>{{cite web | title = Jordanian Food and Drug Administration | url = http://www.jfda.jo/}}</ref>{{failed verification|date=September 2020}}

==References==

{{reflist}}

== External links ==

* {{cite web | url = https://druginfo.nlm.nih.gov/drugportal/name/dexamethasone%20mixture%20with%20tobramycin | publisher = U.S. National Library of Medicine | work = Drug Information Portal | title = Dexamethasone mixture with tobramycin }}

{{AminoglycosideAntiBiotics}}

{{Corticosteroids}}

{{Portal bar | Medicine}}

{{DEFAULTSORT:Tobramycin Dexamethasone}}

[[Category:Antibiotics]]

[[Category:Glucocorticoids]]

[[Category:Combination drugs]]

[[Category:Drugs developed by Novartis]]