ENZYME entry: EC 6.3.4.23

Accepted Name

formate--phosphoribosylaminoimidazolecarboxamide ligase

Alternative Name(s)

5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase

5-formaminoimidazole-4-carboxamide ribonucleotide synthetase

Reaction catalysed

5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate

Comment(s)

This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyzes a step in the synthesis of purine nucleotides.
It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. cf. EC 2.1.2.3.

Cross-references

BRENDA

6.3.4.23

EC2PDB

6.3.4.23

ExplorEnz

6.3.4.23

PRIAM enzyme-specific profiles

6.3.4.23

KEGG Ligand Database for Enzyme Nomenclature

6.3.4.23

IUBMB Enzyme Nomenclature

6.3.4.23

IntEnz

6.3.4.23

MEDLINE

Find literature relating to 6.3.4.23

MetaCyc

6.3.4.23

Rhea expert-curated reactions

6.3.4.23

UniProtKB/Swiss-Prot

Q8PWT3, PURP1_METMA	Q8PT10, PURP2_METMA	O30123, PURP_ARCFU
A8M9J5, PURP_CALMQ	A0RU67, PURP_CENSY	A8A9M3, PURP_IGNH4
B1L3X7, PURP_KORCO	A6UWN1, PURP_META3	Q8TU67, PURP_METAC
Q0W2C6, PURP_METAR	Q46CU6, PURP_METBF	Q12VJ6, PURP_METBU
Q57600, PURP_METJA	Q8TXS2, PURP_METKA	A4FWE6, PURP_METM5
A9A9U0, PURP_METM6	A6VGV9, PURP_METM7	Q6LXH8, PURP_METMP
A5UKI3, PURP_METS3	A4YCP2, PURP_METS5	Q2NHH7, PURP_METST
O27269, PURP_METTH	A0B5K9, PURP_METTP	P14027, PURP_METVS
A9A1D3, PURP_NITMS	Q9V0I8, PURP_PYRAB	Q8ZYV1, PURP_PYRAE
A4WN42, PURP_PYRAR	A3MTB5, PURP_PYRCJ	Q8U0R7, PURP_PYRFU
O59073, PURP_PYRHO	A1RQP5, PURP_PYRIL	B1YBN2, PURP_PYRNV
Q980P7, PURP_SACS2	Q4JAU3, PURP_SULAC	Q975Y9, PURP_SULTO
Q5JFL8, PURP_THEKO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.4.-
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