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On the mechanism of hepatic transendothelial passage of large liposomes.

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Affiliations

  • 1. Groningen University Institute for Drug Exploration, Faculty of Medical Sciences, Department of Physiological Chemistry, University of Groningen, The Netherlands.
      Authors
    • Romero EL 1
    (1 author)

ORCIDs linked to this article

FEBS Letters, 01 Apr 1999, 448(1):193-196
https://doi.org/10.1016/s0014-5793(99)00364-6 PMID: 10217439 

Abstract 

Liposomes of 400 nm in diameter can cross the 100-nm fenestrations in the endothelium of the hepatic sinusoid, provided they contain phosphatidylserine (PS) but not phosphatidylglycerol (PG) [Daemen et al. (1997) Hepatology 26, 416]. We present evidence indicating that (i) the PS effect does not involve a pharmacological action of this lipid on the size of the fenestrations, (ii) fluid-type but not solid-type PS liposomes have access to the hepatocytes and (iii) the lack of uptake of PG liposomes by hepatocytes is not due to a lack of affinity of the hepatocytes for PG surfaces. We conclude that the mechanism responsible for the uptake of large PS-containing liposomes by hepatocytes in vivo involves a mechanical deformation of these liposomes during their passage across the endothelial fenestrations.

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Read article at publisher's site: https://doi.org/10.1016/s0014-5793(99)00364-6

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