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Viral clearance without destruction of infected cells during acute HBV infection.

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Affiliations

  • 1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
      Authors
    • Guidotti LG 1
    (1 author)

ORCIDs linked to this article

Science, 01 Apr 1999, 284(5415):825-829
https://doi.org/10.1126/science.284.5415.825 PMID: 10221919 

Abstract 

Viral clearance during hepatitis B virus (HBV) infection has been thought to reflect the destruction of infected hepatocytes by CD8(+) T lymphocytes. However, in this study, HBV DNA was shown to largely disappear from the liver and the blood of acutely infected chimpanzees long before the peak of T cell infiltration and most of the liver disease. These results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected cells.

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Read article at publisher's site: https://doi.org/10.1126/science.284.5415.825

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Funding 

Funders who supported this work.

NCI NIH HHS (1)

NIAID NIH HHS (2)