The core antigen of hepatitis B virus as a carrier for immunogenic peptides.

Murray K; Shiau AL

doi:10.1515/bc.1999.038

The core antigen of hepatitis B virus as a carrier for immunogenic peptides.

Murray K ¹,

Shiau AL

Affiliations

1. Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, UK.
Authors
Murray K¹
(1 author)

Biological Chemistry, 01 Mar 1999, 380(3):277-283
https://doi.org/10.1515/bc.1999.038 PMID: 10223329

Review

Abstract

The core antigen of hepatitis B virus (HBcAg) made in Escherichia coli yields particles that closely resemble the viral nucleocapsid. Extensive modifications can be made to the primary structure of HBcAg without impairing particle assembly. This enables other peptide sequences, including very long sequences, to be added, substituted, or inserted into the nucleocapsid subunit while retaining the ability to form highly immunogenic particles. These also retain the T cell epitopes of HBcAg and constitute powerful delivery systems for a diverse range of immunogenic epitopes and have significant potential for development of multicomponent vaccines.

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Read article at publisher's site: https://doi.org/10.1515/bc.1999.038

References

Articles referenced by this article (34)

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Yong CY, Yeap SK, Goh ZH, Ho KL, Omar AR, Tan WS
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Phage display creates innovative applications to combat hepatitis B virus.
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World J Gastroenterol, 20(33):11650-11670, 01 Sep 2014
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Search life-sciences literature (45,103,589 articles, preprints and more)

The core antigen of hepatitis B virus as a carrier for immunogenic peptides.

Affiliations

Authors

Abstract

Full text links

References

Mutations that change the immunological subtype of hepatitis B virus surface antigen and distinguish between antigenic and immunogenic determination.

Detection of additional antigenic determinants of hepatitis B antigen.

Recombinant core particles of hepatitis B virus exposing foreign antigenic determinants on their surface.

Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen.

Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy.

Immunological screening method to detect specific translation products.

Rapid detection of hepatitis B surface antigen by double antibody radioimmunoassay.

Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322.

Vaccine-induced escape mutant of hepatitis B virus.

Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

PreS1 Containing HBc VLPs for the Development of a Combined Therapeutic/Prophylactic Hepatitis B Vaccine.

Advances in the study of nodavirus.

Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins.

Induction of humoral and cell-mediated immune responses by hepatitis B virus epitope displayed on the virus-like particles of prawn nodavirus.

Phage display creates innovative applications to combat hepatitis B virus.

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The core antigen of hepatitis B virus as a carrier for immunogenic peptides.

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