Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

The neuroanatomical and neurochemical basis of conditioned fear.

Author information

Affiliations

  • 1. Tierphysiologie, Universität Tübingen, Germany.
      Authors
    • Fendt M 1
    (1 author)

ORCIDs linked to this article

Neuroscience and Biobehavioral Reviews, 01 May 1999, 23(5):743-760
https://doi.org/10.1016/s0149-7634(99)00016-0 PMID: 10392663 

Review

Abstract 

After a few pairings of a threatening stimulus with a formerly neutral cue, animals and humans will experience a state of conditioned fear when only the cue is present. Conditioned fear provides a critical survival-related function in the face of threat by activating a range of protective behaviors. The present review summarizes and compares the results of different laboratories investigating the neuroanatomical and neurochemical basis of conditioned fear, focusing primarily on the behavioral models of freezing and fear-potentiated startle in rats. On the basis of these studies, we describe the pathways mediating and modulating fear. We identify several key unanswered questions and discuss possible implications for the understanding of human anxiety disorders.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/s0149-7634(99)00016-0

References 

Articles referenced by this article (231)

Show 10 more references (10 of 231)

Citations & impact 

Impact metrics

622
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/41563259
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/41563259

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/s0149-7634(99)00016-0

Supporting
Mentioning
Contrasting
22
637
5

Article citations

Go to all (622) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.