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Dual function of the selenoprotein PHGPx during sperm maturation.

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Affiliations

  • 1. Dipartmento di Chimica Biologica, Università di Padova, Viale G. Colombo 3, I-35121 Padova, Italy.
      Authors
    • Ursini F 1
    (1 author)

ORCIDs linked to this article

Science, 01 Aug 1999, 285(5432):1393-1396
https://doi.org/10.1126/science.285.5432.1393 PMID: 10464096 

A comment on this article appears in "Selenium's role in infertility explained." Science. 1999 Aug 27;285(5432):1339.

Abstract 

The selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) changes its physical characteristics and biological functions during sperm maturation. PHGPx exists as a soluble peroxidase in spermatids but persists in mature spermatozoa as an enzymatically inactive, oxidatively cross-linked, insoluble protein. In the midpiece of mature spermatozoa, PHGPx protein represents at least 50 percent of the capsule material that embeds the helix of mitochondria. The role of PHGPx as a structural protein may explain the mechanical instability of the mitochondrial midpiece that is observed in selenium deficiency.

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Read article at publisher's site: https://doi.org/10.1126/science.285.5432.1393

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