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Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis.

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Affiliations

  • 1. Department of Pediatrics, University of California, Los Angeles, California 90095-1752, USA.
      Authors
    • Liu B 1
    (1 author)

ORCIDs linked to this article

The Journal of Biological Chemistry, 01 Oct 2000, 275(43):33607-33613
https://doi.org/10.1074/jbc.m002547200 PMID: 10874028 

Abstract 

Insulin-like growth factor-binding protein (IGFBP)-3 regulates apoptosis in an IGF-independent fashion and has been shown to localize to nuclei. We cloned the nuclear receptor retinoid X receptor-alpha(RXR-alpha) as an IGFBP-3 protein partner in a yeast two-hybrid screen. Multiple methodologies showed that IGFBP-3 and RXR-alpha bind each other within the nucleus. IGFBP-3-induced apoptosis was abolished in RXR-alpha-knockout cells. IGFBP-3 and RXR ligands were additive in inducing apoptosis in prostate cancer cells. IGFBP-3 enhanced RXR response element and inhibited RARE signaling. Thus, RXR-alpha-IGFBP-3 interaction leads to modulation of the transcriptional activity of RXR-alpha and is essential for mediating the effects of IGFBP-3 on apoptosis.

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Read article at publisher's site: https://doi.org/10.1074/jbc.m002547200

Read article for free, from open access legal sources, via Unpaywall: http://www.jbc.org/article/S002192582089053X/pdfUnpaywall

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Funding 

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NIAID NIH HHS (1)

NIDDK NIH HHS (1)