Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

The c-Abl tyrosine kinase contributes to the transient activation of MAP kinase in cells plated on fibronectin.

Author information

Affiliations

  • 1. Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
      Authors
    • Renshaw MW 1
    (1 author)

ORCIDs linked to this article

Oncogene, 01 Jun 2000, 19(28):3216-3219
https://doi.org/10.1038/sj.onc.1203667 PMID: 10918577 

Abstract 

Previous work showed that integrin stimulation triggers activation of the c-Abl tyrosine kinase and its transient localization to focal adhesions. We now report that plating cells on fibronectin triggers association of Grb2 with c-Abl, suggesting possible involvement of c-Abl with integrin activation of the MAP kinase pathway. Expression of a kinase-defective c-Abl specifically inhibited the transient induction of Erk2 activity following cell adhesion. Together with the known ability of activated, oncogenic forms of c-Abl to activate Ras and the MAP kinase pathway, these data suggest that c-Abl contributes to the integrin induction of MAP kinase activity.

Full text links 

Read article at publisher's site: https://doi.org/10.1038/sj.onc.1203667

References 

Articles referenced by this article (30)

Show 10 more references (10 of 30)

Citations & impact 

Impact metrics

9
Citations
Jump to Citations

Citations of article over time

Article citations

Go to all (9) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

NCI NIH HHS (1)

NHLBI NIH HHS (1)

NIGMS NIH HHS (1)