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Mitochondria as the central control point of apoptosis.

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Affiliations

  • 1. UPR CNRS 9023, CCIPE, 141 rue de la Cardonille, F-34094 Montpellier Cedex 5, France.
      Authors
    • Desagher S 1
    (1 author)

ORCIDs linked to this article

Trends in Cell Biology, 01 Sep 2000, 10(9):369-377
https://doi.org/10.1016/s0962-8924(00)01803-1 PMID: 10932094 

Review

A comment on this article appears in "Solange Desagher and Jean-Claude Martinou: Executioners of Cell Death." Trends Cell Biol. 2016 Aug;26(8):560-562.

Abstract 

Mitochondria play a major role in apoptosis triggered by many stimuli. They integrate death signals through Bcl-2 family members and coordinate caspase activation through the release of cytochrome c as a result of the outer mitochondrial membrane becoming permeable. The mechanisms that lead to this permeability are not yet completely understood. Here, we attempt to summarize our current view of the mechanisms that lead to the efflux of many proteins from mitochondria during apoptosis and the role played by Bcl-2 family proteins in the control of this event.

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Read article at publisher's site: https://doi.org/10.1016/s0962-8924(00)01803-1

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