Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter.

Author information

Affiliations

  • 1. Department of Neurology, University of California at San Francisco School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143-0435, USA.
      Authors
    • Bellocchio EE 1
    (1 author)

Science, 01 Aug 2000, 289(5481):957-960
https://doi.org/10.1126/science.289.5481.957 PMID: 10938000 

A comment on this article appears in "Neurobiology. Long-sought protein packages glutamate." Science. 2000 Aug 11;289(5481):847-9.

Abstract 

Previous work has identified two families of proteins that transport classical neurotransmitters into synaptic vesicles, but the protein responsible for vesicular transport of the principal excitatory transmitter glutamate has remained unknown. We demonstrate that a protein that is unrelated to any known neurotransmitter transporters and that was previously suggested to mediate the Na(+)-dependent uptake of inorganic phosphate across the plasma membrane transports glutamate into synaptic vesicles. In addition, we show that this vesicular glutamate transporter, VGLUT1, exhibits a conductance for chloride that is blocked by glutamate.

Full text links 

Read article at publisher's site: https://doi.org/10.1126/science.289.5481.957

Citations & impact 

Impact metrics

543
Citations
Jump to Citations
7
Data citations
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/3515450
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/3515450

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1126/science.289.5481.957

Supporting
Mentioning
Contrasting
35
621
1

Article citations

Go to all (543) article citations

Other citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.