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A role for GATA transcription factors in the androgen regulation of the prostate-specific antigen gene enhancer.

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Affiliations

  • 1. Geriatric Research, Education, and Clinical Center and Research Service, Veterans Affairs Medical Center, Miami, FL 33125, USA.
      Authors
    • Perez-Stable CM 1
    (1 author)

Molecular and Cellular Endocrinology, 01 Sep 2000, 167(1-2):43-53
https://doi.org/10.1016/s0303-7207(00)00300-2 PMID: 11000519 

Abstract 

The transgenic mouse line Ggamma/T-15 containing the fetal globin promoter linked to SV40 T antigen unexpectedly results in androgen-independent prostate carcinomas. Given the key role of GATA-1 transcription factor in fetal globin gene promoter activity, we investigated whether specific GATA family members are expressed in the prostate and whether they can regulate prostate-specific genes. We found that GATA-2 and -3 are the predominant GATA family members expressed in human and mouse prostate and that GATA mRNA levels are not regulated by androgen. We identified six GATA sites flanking an androgen-response element located in the far-upstream enhancer of the prostate-specific antigen (PSA) gene. These GATA sites are targets for GATA factors and are essential for optimal androgen induction of transfected PSA enhancer/promoter plasmids in LNCaP, a PSA and androgen receptor expressing human prostate cancer cell line. Our results suggest that prostatic GATA-2 and -3 are involved in the androgen regulation of the PSA gene.

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Read article at publisher's site: https://doi.org/10.1016/s0303-7207(00)00300-2

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NCI NIH HHS (1)