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Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.

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Affiliations

  • 1. Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
      Authors
    • Shimoda K 1
    (1 author)

ORCIDs linked to this article

Immunity, 01 Oct 2000, 13(4):561-571
https://doi.org/10.1016/s1074-7613(00)00055-8 PMID: 11070174 

Abstract 

Janus kinases (Jaks) play an important role in signal transduction via cytokine receptors. Tyk2 is a Janus kinase, and we developed tyk2-deficient mice to study the requirement for tyk2 in vivo. Tyk2-deficient mice show no overt developmental abnormalities; however, they display a lack of responsiveness to a small amount of IFNalpha, although a high concentration of IFNalpha can fully transduce its signal even in the absence of tyk2. Furthermore, IL-12-induced T cell function is defective in these mice. In contrast, these mice respond normally to IL-6 and IL-10, both of which activate tyk2 in vitro. These observations demonstrate that tyk2 plays only a restricted role in mediating IFNalpha-dependent signaling while being required in mediating IL-12-dependent biological responses.

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Read article at publisher's site: https://doi.org/10.1016/s1074-7613(00)00055-8

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Ministry of Education, Culture, Sports, Science and Technology