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The mGlu5 receptor agonist CHPG stimulates striatal glutamate release: possible involvement of A2A receptors.

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  • 1. Pharmacology Department, Istituto Superiore di Sanitá, Roma, Italy.
      Authors
    • Pintor A 1
    (1 author)

Neuroreport, 01 Nov 2000, 11(16):3611-3614
https://doi.org/10.1097/00001756-200011090-00042 PMID: 11095529 

Abstract 

The intrastriatal perfusion of the selective metabotropic glutamate (mGlu)5 receptor agonist (RS)-2-chloro-5-hydroxy-phenylglycine (CHPG, 1000 microM) significantly increased (approximately + 100%, p < 0.05) glutamate extracellular levels with respect to basal values. The potentiating effect of CHPG was prevented by the selective mGlu5 receptor antagonist 2-methyl-6(phenyl-ethynyl)-pyridine (MPEP, 250 microM)) and by the adenosine A2A receptor antagonist SCH 58261 (2 mg/kg, i.p.). The results show that mGlu5 receptors are involved in the regulation of striatal glutamate release and suggest an involvement of adenosine A2A receptors in mGlu5 receptor-mediated effects.

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Read article at publisher's site: https://doi.org/10.1097/00001756-200011090-00042

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