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Chromosomal passengers and the (aurora) ABCs of mitosis.

Affiliations

1. Wellcome Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Mayfield Road, EH9 3JR, Edinburgh, UK.
Authors
Adams RR¹
(1 author)

ORCIDs linked to this article

Trends in Cell Biology, 01 Feb 2001, 11(2):49-54
https://doi.org/10.1016/s0962-8924(00)01880-8 PMID: 11166196

Review

Abstract

Chromosomal passengers are proteins that move from centromeres to the spindle midzone during mitosis. Recent experiments show that the passengers inner centromere protein (INCENP) and aurora-B kinase are in a macromolecular complex that might also contain a third passenger, survivin. The chromosomal passenger complex functions throughout mitosis in chromosome condensation and segregation, and at the end of mitosis, in the completion of cytokinesis.

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Read article at publisher's site: https://doi.org/10.1016/s0962-8924(00)01880-8

References

Articles referenced by this article (35)

Chromosomal passengers: Towards an integrated view of mitosis
Earnshaw
Chromosoma 1990
Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis.
Martineau-Thuillier S, Andreassen PR, Margolis RL
Chromosoma, (6-7):461-470 1998
MED: 9914378
The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis.
Cooke CA, Heck MM, Earnshaw WC
J Cell Biol, (5):2053-2067 1987
MED: 3316246
A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis.
Mackay AM, Ainsztein AM, Eckley DM, Earnshaw WC
J Cell Biol, (5):991-1002 1998
MED: 9490714
Chromosomal proteins and cytokinesis: patterns of cleavage furrow formation and inner centromere protein positioning in mitotic heterokaryons and mid-anaphase cells.
Eckley DM, Ainsztein AM, Mackay AM, Goldberg IG, Earnshaw WC
J Cell Biol, (6):1169-1183 1997
MED: 9087435
Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice.
Cutts SM, Fowler KJ, Kile BT, Hii LL, O'Dowd RA, Hudson DF, Saffery R, Kalitsis P, Earle E, Choo KH
Hum Mol Genet, (7):1145-1155 1999
MED: 10369859
The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.
Bischoff JR, Plowman GD
Trends Cell Biol, (11):454-459 1999
MED: 10511710
Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.
Giet R, Prigent C
J Cell Sci, 3591-3601 1999
MED: 10523496
The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast.
Biggins S, Severin FF, Bhalla N, Sassoon I, Hyman AA, Murray AW
Genes Dev, (5):532-544 1999
MED: 10072382
The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5.
Giet R, Uzbekov R, Cubizolles F, Le Guellec K, Prigent C
J Biol Chem, (21):15005-15013 1999
MED: 10329703

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Wikipedia

https://en.wikipedia.org/wiki/Aurora_B_kinase

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This data has been provided by curated databases and other sources that have cited the article.

FlyBase

http://flybase.org/cgi-bin/uniq.html?db=fbrf&field=pubmed_id&context=11166196

Proteins in UniProt (Showing 5 of 14)

Kinesin-like protein(UniProt - Q8SXT9)
Kinesin-like protein(UniProt - O62528)
Kinesin-like protein Klp61F(UniProt - P46863)
Kinesin motor domain-containing protein(UniProt - Q0PQ30)
Aurora kinase(UniProt - Q27393)

Go to all (14) records in UniProt

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Funding

Funders who supported this work.

Wellcome Trust (1)

The role of non-histon proteins in chromosome structure and function during mitosis and apoptosis.
Prof William Earnshaw, University of Edinburgh
Grant ID: 073915
212 publications