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Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey.

Science, 01 Aug 1979, 205(4409):929-932
https://doi.org/10.1126/science.112679 PMID: 112679 

Abstract 

Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed alternation performance nearly as severe as that caused by surgical ablation of the same area. This behavioral deficit can be pharmacologically reversed with dopamine agonists such as L-dopa and apomorphine. These data provide direct evidence that dopamine plays an important role in a specific cortical function.

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Read article at publisher's site: https://doi.org/10.1126/science.112679

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