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Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences.

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Affiliations

  • 1. Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
      Authors
    • Bjartmar C 1
    (1 author)

Current Opinion in Neurology, 01 Jun 2001, 14(3):271-278
https://doi.org/10.1097/00019052-200106000-00003 PMID: 11371748 

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Abstract 

Renewed interest in axonal injury in multiple sclerosis has significantly shifted the focus of research into this disease toward neurodegeneration. During the past year magnetic resonance and morphologic studies have continued to confirm and extend the concept that axonal transection begins at disease onset, and that cumulative axonal loss provides the pathologic substrate for the progressive disability that most long-term MS patients experience. Although inflammation and chronic demyelination are probable causes of axonal transection, little is known about the molecular mechanisms that are involved. The view that MS can also be considered an inflammatory neurodegenerative disease has important clinical implications for therapeutic approaches, monitoring of patients, and future treatment strategies.

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Read article at publisher's site: https://doi.org/10.1097/00019052-200106000-00003

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Funding 

Funders who supported this work.

NINDS NIH HHS (2)