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An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.

Author information

Affiliations

  • 1. Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA.
      Authors
    • Schiemann B 1
    (1 author)

ORCIDs linked to this article

Science, 16 Aug 2001, 293(5537):2111-2114
https://doi.org/10.1126/science.1061964 PMID: 11509691 

A comment on this article appears in "Immunology. Long live the mature B cell--a baffling mystery resolved." Science. 2001 Sep 14;293(5537):2012-3.

Abstract 

The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.

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Read article at publisher's site: https://doi.org/10.1126/science.1061964

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