Chemokines and central nervous system disorders.

Karpus WJ

doi:10.1080/135502801753248079

Chemokines and central nervous system disorders.

Karpus WJ ¹

Affiliations

1. Department of Pathology, Northwestern University Medical School, 303 E. Chicago Avenue, W127, Chicago, IL 60611, USA.
Authors
Karpus WJ¹
(1 author)

ORCIDs linked to this article

Karpus WJ | 0000-0001-9541-3139

Journal of Neurovirology, 01 Dec 2001, 7(6):493-500
https://doi.org/10.1080/135502801753248079 PMID: 11704881

Review

Abstract

Chemokines and their receptors are large families of inflammatory molecules responsible for a number of biologic functions including the accumulation of leukocytes at tissue sites. Over the past 8 years, a number of studies have indicated a role for chemokines in the pathogenesis of CNS inflammatory diseases. This minireview provides a brief summary of our current knowledge of chemokines and CNS inflammatory diseases including experimental autoimmune encephalomyelitis, multiple sclerosis, virus-induced demyelinating diseases, Alzheimer's disease, and central nervous system bacterial-induced diseases.

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Read article at publisher's site: https://doi.org/10.1080/135502801753248079

References

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Funding

Funders who supported this work.

NIAID NIH HHS (1)

Grant ID: AI 35934
1 publication

NINDS NIH HHS (1)

Grant ID: NS 34510
1 publication

Search life-sciences literature (45,105,671 articles, preprints and more)

Chemokines and central nervous system disorders.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Biphasic and regionally-restricted chemokine expression in the central nervous system in the Theiler's virus model of multiple sclerosis.

Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains.

Neutralization of macrophage inflammatory protein 2 (MIP-2) and MIP-1alpha attenuates neutrophil recruitment in the central nervous system during experimental bacterial meningitis.

Identification and characterization of small molecule functional antagonists of the CCR1 chemokine receptor.

Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent.

Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis.

Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis.

Amyloid-beta induces chemokine secretion and monocyte migration across a human blood--brain barrier model.

Chemokine receptor antagonism as a new therapy for multiple sclerosis.

Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes.

Citations & impact

Impact metrics

Citations of article over time

Article citations

Elevated expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain.

Enterovirus 71 infection increases expression of interferon-gamma-inducible protein 10 which protects mice by reducing viral burden in multiple tissues.

Possible therapeutic uses of Salvia triloba and Piper nigrum in Alzheimer's disease-induced rats.

Genotypical diversity of HIV clades and central nervous system impairment.

Relationship between inflammatory mediators, Aβ levels and ApoE genotype in Alzheimer disease.

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NINDS NIH HHS (1)

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Search life-sciences literature (45,105,671 articles, preprints and more)

Chemokines and central nervous system disorders.

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Abstract

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References

Citations & impact

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Funding

NIAID NIH HHS (1)﻿

NINDS NIH HHS (1)﻿

Partnerships & funding

NIAID NIH HHS (1)

NINDS NIH HHS (1)