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Sibling rivalry in the E2F family.

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  • 1. Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
      Authors
    • Trimarchi JM 1
    (1 author)

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Nature reviews. Molecular Cell Biology, 01 Jan 2002, 3(1):11-20
https://doi.org/10.1038/nrm714 PMID: 11823794 

Review

Abstract 

The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me-pull-you' regulation, and what are its biological consequences?

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Read article at publisher's site: https://doi.org/10.1038/nrm714

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