A conserved mRNA export machinery coupled to pre-mRNA splicing.

Reed R; Hurt E

doi:10.1016/s0092-8674(02)00627-x

Abstract

Recent advances have led to a new understanding of how mRNAs are exported from the nucleus to the cytoplasm. This process requires a heterodimeric mRNA export receptor that is part of an elaborate machinery conserved from yeast to humans. Export of mRNAs is coupled to upstream steps in gene expression, such as pre-mRNA splicing, and to downstream events, including nonsense-mediated decay.

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References

Articles referenced by this article (93)

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Proteins in UniProt (Showing 5 of 10)

mRNA transport regulator MTR2(UniProt - P34232)
mRNA export factor MEX67(UniProt - Q99257)
mRNA export factor GLE2(UniProt - P40066)
Nucleoporin NUP159(UniProt - P40477)
Serine/arginine (SR)-type shuttling mRNA binding protein NPL3(UniProt - Q01560)

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Saccharomyces Genome Database

https://www.yeastgenome.org/reference/S000142053

Search life-sciences literature (45,103,589 articles, preprints and more)

A conserved mRNA export machinery coupled to pre-mRNA splicing.

Affiliations

Authors

Abstract

Full text links

References

Proteomic analysis of nucleoporin interacting proteins.

The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.

Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.

Identification of novel import and export signals of human TAP, the protein that binds to the constitutive transport element of the type D retrovirus mRNAs.

Coupling RNA polymerase II transcription with pre-mRNA processing.

Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export.

Protein ligands to HuR modulate its interaction with target mRNAs in vivo.

Pre-mRNA processing factors are required for nuclear export.

A mutation in the Schizosaccharomyces pombe rae1 gene causes defects in poly(A)+ RNA export and in the cytoskeleton.

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/s0092-8674(02)00627-x

Article citations

Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency.

Designing and optimizing AAV-mediated gene therapy for neurodegenerative diseases: from bench to bedside.

Size-dependent enhancement of gene expression by Plasmodium 5'UTR introns.

Causal ALS genes impact the MHC class II antigen presentation pathway.

Introns and Their Therapeutic Applications in Biomedical Researches.

Other citations

Wikipedia (2)

Data

Data that cites the article

Proteins in UniProt (Showing 5 of 10)

Saccharomyces Genome Database

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Search life-sciences literature (45,103,589 articles, preprints and more)

A conserved mRNA export machinery coupled to pre-mRNA splicing.

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Data

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Proteins in UniProt (Showing 5 of 10)

Saccharomyces Genome Database

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