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NF-kappaB regulation in the immune system.

Author information

Affiliations

  • 1. The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
      Authors
    • Li Q 1
    (1 author)

Nature reviews. Immunology, 01 Oct 2002, 2(10):725-734
https://doi.org/10.1038/nri910 PMID: 12360211 

Review

This article has been corrected. See Nat Rev Immunol 2002 Dec;2(12):975.

Abstract 

The nuclear factor-kappaB (NF-kappaB)/REL family of transcription factors has a central role in coordinating the expression of a wide variety of genes that control immune responses. There has been intense scientific activity in the NF-kappaB field owing to the involvement of these factors in the activation and regulation of key molecules that are associated with diseases ranging from inflammation to cancer. In this review, we focus on our current understanding of NF-kappaB regulation and its role in the immune system and inflammatory diseases. We also discuss the role of NF-kappaB proteins as potential therapeutic targets in clinical applications.

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