Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Dominant transplantation tolerance impairs CD8+ T cell function but not expansion.

Author information

Affiliations

  • 1. Sir William Dunn School of Pathology, University of Oxford, UK.
      Authors
    • Lin CY 1
    (1 author)

ORCIDs linked to this article

Nature Immunology, 04 Nov 2002, 3(12):1208-1213
https://doi.org/10.1038/ni853 PMID: 12415266 

Abstract 

Alloreactive CD8+ T cells may persist in animals made tolerant of transplanted tissues; their function is controlled through continuous censorship by regulatory CD4+ T cells. We sought to establish the stage at which such censorship operates. We found that monospecific CD8+ T cells introduced into tolerant animals responded to the tolerated tissue antigen as if they had received CD4+ T cell "help": they proliferated and accumulated normally. However, they did show compromised graft rejection, interferon-gamma production and cell-mediated cytotoxicity. These findings suggest that tolerance mediated by regulatory T cells acts by censoring immune effector functions rather than by limiting the induction of T cell responses.

Full text links 

Read article at publisher's site: https://doi.org/10.1038/ni853

References 

Articles referenced by this article (50)

Show 10 more references (10 of 50)

Citations & impact 

Impact metrics

101
Citations
Jump to Citations
4
Data citations
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/42696964
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/42696964

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1038/ni853

Supporting
Mentioning
Contrasting
13
106
1

Article citations

Go to all (101) article citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.