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Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model.

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Affiliations

  • 1. Department of Psychology, Washington University, St. Louis, Missouri 63130, USA.
      Authors
    • Miller GE 1
    (1 author)

ORCIDs linked to this article

Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association, 01 Nov 2002, 21(6):531-541
https://doi.org/10.1037//0278-6133.21.6.531 PMID: 12433005 

Abstract 

This study examined whether chronic stress impairs the immune system's capacity to respond to hormonal signals that terminate inflammation. Fifty healthy adults were studied; half were parents of cancer patients, and half were parents of healthy children. Parents of cancer patients reported more psychological distress than parents of healthy children. They also had flatter diurnal slopes of cortisol secretion, primarily because of reduced output during the morning hours. There was also evidence that chronic stress impaired the immune system's response to anti-inflammatory signals: The capacity of a synthetic glucocorticoid hormone to suppress in vitro production of the pro-inflammatory cytokine interleukin-6 was diminished among parents of cancer patients. Findings suggest a novel pathway by which chronic stress might alter the course of inflammatory disease.

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Read article at publisher's site: https://doi.org/10.1037//0278-6133.21.6.531

Read article for free, from open access legal sources, via Unpaywall: https://figshare.com/articles/journal_contribution/Chronic_Psychological_Stress_and_the_Regulation_of_Pro-Inflammatory_Cytokines_A_Glucocorticoid-Resistance_Model/6613931/1/files/12106589.pdfUnpaywall

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Funding 

Funders who supported this work.

NHLBI NIH HHS (2)

NIMH NIH HHS (3)