Cell surface carbohydrate determinants figure heavily in the regulation of lymphocyte homing and the inflammatory recruitment of leukocytes. The recently described sulfated carbohydrate ligand for selectins, sialyl 6-sulfo Lewis x, is mainly involved in the routine homing of various subsets of lymphocytes, such as nai;ve helper T cells, and skin- and gut-homing helper memory T cells. The homing of lymphocytes is regulated by a unique post-translational modification of sialic acid moieties that occurs specifically in sulfated selectin ligands, whereby the sialic acid loses its N-acetyl group and is converted into a 1-5 cyclic derivative. By contrast, nonsulfated carbohydrate ligands of the selectins, such as sialyl Lewis x, are mainly involved in the recruitment of leukocytes during inflammation. The increment of sialyl Lewis x expression upon inflammatory stimuli is mediated by transcriptional induction of fucosyltransferase genes.