Rocks: multifunctional kinases in cell behaviour.

Riento K; Ridley AJ

doi:10.1038/nrm1128

Rocks: multifunctional kinases in cell behaviour.

Riento K ¹,

Ridley AJ

Affiliations

1. Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK.
Authors
Riento K¹
(1 author)

Nature reviews. Molecular Cell Biology, 01 Jun 2003, 4(6):446-456
https://doi.org/10.1038/nrm1128 PMID: 12778124

Review

Abstract

ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.

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References

Articles referenced by this article (146)

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Gene Ontology Annotation Project

https://www.ebi.ac.uk/QuickGO/annotations?reference=12778124

Proteins in UniProt (2)

Rho-associated protein kinase 2(UniProt - O75116)
Rho-associated protein kinase 1(UniProt - Q13464)

GlyGen is an international glycobioinformatics knowledgebase funded by The National Institutes of Health to facilitate glycoscience research by integrating diverse kinds of information, including glycomics, genomics, proteomics (and glycoproteomics), cell biology, developmental biology and biochemistry.

https://www.glygen.org/publication/MED/12778124

Protein families in InterPro

ROCK1_HR1(InterPro - IPR037310)

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Rocks: multifunctional kinases in cell behaviour.

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